Breast cancer recurrence following prosthetic, postmastectomy reconstruction: Incidence, detection, and treatment Journal Article
| Authors: | McCarthy, C. M.; Pusic, A. L.; Sclafani, L.; Buchanan, C.; Fey, J. V.; Disa, J. J.; Mehrara, B. J.; Cordeiro, P. G. |
| Article Title: | Breast cancer recurrence following prosthetic, postmastectomy reconstruction: Incidence, detection, and treatment |
| Abstract: | BACKGROUND: The purpose of this study was to evaluate the influence of prosthetic reconstruction on the incidence, detection, and management of locoregional recurrence following mastectomy for invasive breast cancer. METHODS: A matched retrospective cohort study was performed. Only patients with invasive breast cancer who had 2 years or more of follow-up and/or patients who had recurrence within 2 years of their primary cancer were included. RESULTS: In total, 618 patients who underwent mastectomy for invasive breast cancer from 1995 until 1999 were evaluated. Three hundred nine patients who had immediate, tissue expander/implant reconstruction were matched to 309 women who underwent mastectomy alone on the basis of age (±5 years) and breast cancer stage (I, II, or III). The incidence of locoregional recurrence following mastectomy was 6.8 percent in patients who had reconstruction and 8.1 percent in patients who had mastectomy alone (log rank p = 0.6015). Median time to detection of a locoregional recurrence was 2.3 years (range, 0.1 to 7.2 years) in the reconstructed cohort and 1.9 years (range, 0.1 to 8.8 years) in the nonreconstructed cohort (p = 0.733). Permanent implants were removed following infection in one patient and patient request in two. CONCLUSIONS: These results suggest that there is no difference in the incidence of locoregional recurrence in breast cancer patients who undergo immediate, tissue expander/implant reconstruction compared with those patients who do not have reconstruction. Prosthetic breast reconstruction does not appear to hinder detection of locoregional cancer recurrence. In the majority of patients, management of locoregional recurrence does not necessitate removal of a permanent prosthesis. ©2008American Society of Plastic Surgeons. |
| Keywords: | adult; cancer chemotherapy; controlled study; treatment outcome; aged; middle aged; cancer surgery; retrospective studies; major clinical study; cancer recurrence; multimodality cancer therapy; cancer radiotherapy; comparative study; combined modality therapy; cancer staging; follow up; methodology; follow-up studies; antineoplastic agent; cancer diagnosis; cancer incidence; computer assisted tomography; neoplasm recurrence, local; breast cancer; mastectomy; incidence; tomography, x-ray computed; breast neoplasms; breast reconstruction; mammaplasty; retrospective study; time; time factors; cancer hormone therapy; postoperative complication; postoperative complications; instrumentation; tumor recurrence; breast tumor; breast endoprosthesis; breast implants; estrogen receptor; progesterone receptor; breast augmentation; ageism; breast implantation; prosthesis infection |
| Journal Title: | Plastic and Reconstructive Surgery |
| Volume: | 121 |
| Issue: | 2 |
| ISSN: | 0032-1052 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2008-02-01 |
| Start Page: | 381 |
| End Page: | 388 |
| Language: | English |
| DOI: | 10.1097/01.prs.0000298316.74743.dd |
| PUBMED: | 18300953 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 18" - "Export Date: 17 November 2011" - "CODEN: PRSUA" - "Source: Scopus" |
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