Translational control and cancer therapy Journal Article

Authors: Mavrakis, K. J.; Wendel, H. G.
Article Title: Translational control and cancer therapy
Abstract: Our recent findings on Rheb and eIF4E address key questions of translational control in cancer and have implications for tumor therapy. 1 Briefly, we find that Rheb a proximal activator of mTORC1 and protein translation can cooperate with c-Myc in tumorigenesis in vivo in a manner resembling Akt or the oncogenic eIF4E translation initiation factor. Rheb is highly expressed in some human lymphomas as well as other cancers and likely contributes to malignancies in different tissues.2 The cancer-relevant activities emanating from increased Rheb depend on activation of mTORC1 and are sensitive to rapamycin. Moreover, farnesyltransferase inhibitors (FTIs) can directly block Rheb activity and this is responsible for the therapeutic effect of these drugs in certain tumors. We will discuss here how translational control mechanisms contribute to oncogenesis and speculate on the potential and limitations of targeting these co-operating oncogenic events for therapy. ©2008 Landes Bioscience.
Keywords: protein kinase b; protein expression; nonhuman; protein function; translation initiation; neoplasms; animals; protein kinases; cancer therapy; carcinogenesis; mammalian target of rapamycin; lymphoma; protein farnesyltransferase inhibitor; rna translation; protein biosynthesis; short survey; oncogene c myc; proto-oncogene proteins c-myc; rapamycin; eukaryotic initiation factor-4e; chickens; mouse model; in vivo culture; monomeric gtp-binding proteins; eif4e; rheb; rheb protein
Journal Title: Cell Cycle
Volume: 7
Issue: 18
ISSN: 1538-4101
Publisher: Taylor & Francis Inc.  
Date Published: 2008-09-15
Start Page: 2791
End Page: 2794
Language: English
PUBMED: 18787409
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Hans Guido Wendel
    86 Wendel