TGFβ in Cancer Journal Article
| Author: | Massague, J. |
| Article Title: | TGFβ in Cancer |
| Abstract: | The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and its misregulation can result in tumor development. The regulatory cytokine TGFβ exerts tumor-suppressive effects that cancer cells must elude for malignant evolution. Yet, paradoxically, TGFβ also modulates processes such as cell invasion, immune regulation, and microenvironment modification that cancer cells may exploit to their advantage. Consequently, the output of a TGFβ response is highly contextual throughout development, across different tissues, and also in cancer. The mechanistic basis and clinical relevance of TGFβ's role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; disease course; review; protein function; neoplasm; neoplasms; animal; metabolism; animals; mesenchyme cell; metastasis; apoptosis; bone morphogenetic protein; smad protein; transforming growth factor beta; cell line; cell differentiation; immunoregulation; cancer inhibition; drug antagonism; cell transformation; disease progression; cancer cell; autocrine effect; fibroblast; stroma; epithelium cell; microenvironment; immunity; myofibroblast; dna binding; stroma cell; cell aging; cell invasion; pleiotropy; cytostasis; metazoa; modulation; mitogenic agent; muellerian inhibiting factor; carcinogenic activity; bone morphogenetic protein 9; membrane receptor |
| Journal Title: | Cell |
| Volume: | 134 |
| Issue: | 2 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2008-07-25 |
| Start Page: | 215 |
| End Page: | 230 |
| Language: | English |
| DOI: | 10.1016/j.cell.2008.07.001 |
| PUBMED: | 18662538 |
| PROVIDER: | scopus |
| PMCID: | PMC3512574 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 443" - "Export Date: 17 November 2011" - "CODEN: CELLB" - "Source: Scopus" |
