Efficient synthesis of a novel resorcyclide as anticancer agent based on Hsp90 inhibition Journal Article
| Authors: | Lei, X.; Danishefsky, S. J. |
| Article Title: | Efficient synthesis of a novel resorcyclide as anticancer agent based on Hsp90 inhibition |
| Abstract: | The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological evaluation of triazole-cycloproparadicicol is also reported. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | heat shock protein 90; total synthesis; antitumor agents; click chemistry; triazole-cycloproparadicicol |
| Journal Title: | Advanced Synthesis and Catalysis |
| Volume: | 350 |
| Issue: | 11-12 |
| ISSN: | 1615-4150 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 2008-08-04 |
| Start Page: | 1677 |
| End Page: | 1681 |
| Language: | English |
| DOI: | 10.1002/adsc.200800187 |
| PROVIDER: | scopus |
| PMCID: | PMC3062907 |
| PUBMED: | 21442009 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: JPCHF" - "Source: Scopus" |
