Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus Journal Article


Authors: Ganly, I.; Yang, L.; Giese, R. A.; Hao, Y.; Nossa, C. W.; Morris, L. G. T.; Rosenthal, M.; Migliacci, J.; Kelly, D.; Tseng, W.; Hu, J.; Li, H.; Brown, S.; Pei, Z.
Article Title: Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus
Abstract: Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC-SCC in nonsmoking HPV negative patients. We compared the oral microbiome of HPV-negative nonsmoker OC-SCC(n = 18), premalignant lesions(PML) (n = 8) and normal control patients (n = 12). Their oral microbiome was sampled by oral wash and defined by 16S rRNA gene sequencing. We report that the periodontal pathogens Fusobacterium, Prevotella, Alloprevotella were enriched while commensal Streptococcus depleted in OC-SCC. Based on the four genera plus a marker genus Veillonella for PML, we classified the oral microbiome into two types. Gene/pathway analysis revealed a progressive increase of genes encoding HSP90 and ligands for TLRs 1, 2 and 4 along the controls→PML → OC-SCC progression sequence. Our findings suggest an association between periodontal pathogens and OC-SCC in non smoking HPV negative patients. © 2019 UICC
Keywords: risk factor; leukoplakia; fusobacterium; streptococcus; microbiome; oral cavity squamous cell carcinoma; nonsmoking; periodontal pathogens
Journal Title: International Journal of Cancer
Volume: 145
Issue: 3
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 2019-08-01
Start Page: 775
End Page: 784
Language: English
DOI: 10.1002/ijc.32152
PUBMED: 30671943
PROVIDER: scopus
PMCID: PMC6554043
DOI/URL:
Notes: Article -- Source: Scopus
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MSK Authors
  1. Luc Morris
    281 Morris
  2. Ian Ganly
    432 Ganly
  3. Jocelyn C Migliacci
    104 Migliacci
  4. Rachel Anne Giese
    14 Giese