Histologic spectrum and outcome of Human papillomavirus (HPV)-associated oral cavity squamous cell carcinoma: A single center experience and a survey of The Cancer Genome Atlas (TGCA) cohort Journal Article
| Authors: | Ghossein, R. A.; Dogan, S.; Cohen, M. A.; Katabi, N.; Xu, B. |
| Article Title: | Histologic spectrum and outcome of Human papillomavirus (HPV)-associated oral cavity squamous cell carcinoma: A single center experience and a survey of The Cancer Genome Atlas (TGCA) cohort |
| Abstract: | While high-risk human papillomavirus (HPV) serves as an essential pathogen and an important prognostic and predictive biomarker for oropharyngeal squamous cell carcinoma, it occurs at low frequency (2.2–6%) in oral cavity squamous cell carcinoma (OCSCC). To date, the pathologic features of HPV-associated OCSCC (HPV(+)-OCSCC) have been sparsely reported and its prognosis is not well-defined. We herein described detailed clinicopathologic features and outcomes of a retrospective series of 27 HPV(+)-OCSCC, including 13 from Memorial Sloan Kettering Cancer Center (MSKCC) and 14 from The Cancer Genomic Atlas program (TCGA). The frequency of HPV positivity in OCSCC was 0.7% in MSKCC cohort and 4.9% in TCGA cohort. Although HPV(+)-OCSCC was predominantly non-keratinizing (in 81%) with various degree of maturation, its histologic spectrum was expanded to include keratinizing subtype (19%), adenosquamous carcinoma (7%), and papillary architecture (subtype, 7%). HPV(+)-OCSCC predominantly affected male patients (male:female ratio = 12.5:1) and (ex) smokers (77%). It might occur in mandibular mucosa, floor of mouth, tongue, retromolar trigone, buccal mucosa, maxillary mucosa, or hard palate. In oral cavity, positivity of HPV by RNA in situ hybridization was required, and p16 immunohistochemistry alone was insufficient to confirm the HPV + status. The positive predictive value of p16 immunopositivity in detecting HPV infection was 68%. HPV-positivity did not appear to affect outcomes, including disease specific survival and progression free survival in OCSCC. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. |
| Keywords: | immunohistochemistry; adult; cancer survival; human tissue; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; genetics; clinical feature; histopathology; mortality; cancer localization; cancer recurrence; squamous cell carcinoma; carcinoma, squamous cell; cancer staging; lymph node metastasis; sensitivity and specificity; disease association; protein p16; progression free survival; tumor volume; cohort analysis; smoking; pathology; retrospective study; tumor marker; cancer mortality; distant metastasis; sex ratio; virology; rna; in situ hybridization; cancer center; diagnosis; adenosquamous carcinoma; papillary carcinoma; alcohol consumption; isolation and purification; disease specific survival; mouth neoplasms; cancer morphology; predictive value; anaplastic carcinoma; p16; mouth cavity; wart virus; papillomavirus infections; head and neck squamous cell carcinoma; bowen disease; complication; mouth squamous cell carcinoma; clinical outcome; mucosa; mouth tumor; papillomavirus infection; keratinization; papillomaviridae; cancer prognosis; mandible cancer; very elderly; oral cavity squamous cell carcinoma; human papillomavirus (hpv); humans; human; male; female; article; biomarkers, tumor; squamous cell carcinoma of head and neck; maxilla cancer; buccal mucosa; tongue squamous cell carcinoma; mouth floor; current smoker; ex-smoker; human papillomavirus viruses; neoplasms by histologic type; alveolar ridge; buccal mucosa cancer; gingival squamous cell carcinoma; hard palate carcinoma; lip squamous cell carcinoma |
| Journal Title: | Virchows Archiv |
| Volume: | 485 |
| Issue: | 4 |
| ISSN: | 0945-6317 |
| Publisher: | Springer |
| Date Published: | 2024-10-01 |
| Start Page: | 665 |
| End Page: | 674 |
| Language: | English |
| DOI: | 10.1007/s00428-024-03837-1 |
| PUBMED: | 39289237 |
| PROVIDER: | scopus |
| PMCID: | PMC11875009 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Bin Xu -- Source: Scopus |
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