Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An international collaborative study Journal Article
| Authors: | Ebrahimi, A.; Gil, Z.; Amit, M.; Yen, T. C.; Liao, C. T.; Chaturvedi, P.; Agarwal, J. P.; Kowalski, L. P.; Köhler, H. F.; Kreppel, M.; Cernea, C. R.; Brandao, J.; Bachar, G.; Villaret, A. B.; Fliss, D. M.; Fridman, E.; Robbins, K. T.; Shah, J. P.; Patel, S. G.; Clark, J. R.; for the International Consortium for Outcome Research (ICOR) in Head and Neck Cancer |
| Article Title: | Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An international collaborative study |
| Abstract: | Background: We aimed to investigate whether depth of invasion (DOI) should be an independent indication for postoperative radiotherapy (PORT) in small oral squamous cell carcinomas (SCC). Methods: Retrospective analysis of DOI (<5, 5 to <10, ≥10 mm) and disease-specific survival (DSS) in a multi-institutional international cohort of 1409 patients with oral SCC ≤4 cm in size treated between 1990-2011. Results: In patients without other adverse factors (nodal metastases; close [<5 mm] or involved margins), there was no association between DOI and DSS, with an excellent prognosis irrespective of depth. In the absence of PORT, the 5-year disease-specific mortality was 10% with DOI ≥10 mm, 8% with DOI 5-10 mm, and 6% with DOI <5 mm (P =.169), yielding an absolute risk difference of only 4%. Conclusion: The deterioration in prognosis with increasing DOI largely reflects an association with other adverse features. In the absence of these, depth alone should not be an indication for PORT outside a clinical trial. © 2019 Wiley Periodicals, Inc. |
| Keywords: | survival; radiotherapy; head and neck cancer; locoregional control; tumor thickness; depth of invasion; oral squamous cell carcinoma |
| Journal Title: | Head & Neck |
| Volume: | 41 |
| Issue: | 6 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2019-06-01 |
| Start Page: | 1935 |
| End Page: | 1942 |
| Language: | English |
| DOI: | 10.1002/hed.25633 |
| PUBMED: | 30801885 |
| PROVIDER: | scopus |
| PMCID: | PMC6563806 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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