Marrow transplants from unrelated donors - The authors reply Journal Article

  


Authors: Kernan, N. A.; Hansen, J. A.; Blume, K. G.
Article Title: Marrow transplants from unrelated donors - The authors reply
Abstract: To the Editor: Kernan et al. (March 4 issue)1 report that patients who received marrow mismatched for one HLA antigen, as opposed to none, had delayed engraftment and an increased risk of a relapse of leukemia. However, there was no difference in the incidence of acute or chronic graft-versus-host disease, the incidence of secondary graft failure, or the Karnofsky score. These encouraging results suggest that more transplantations of marrow mismatched for one HLA antigen will be performed in the future. The paper describes HLA mismatches as minor if the mismatched antigen was cross-reactive and as major if the antigen was... © 1993, Massachusetts Medical Society. All rights reserved.
Keywords: survival; letter; allele; chronic myeloid leukemia; hla matching; tissue donors; amino acid sequence; hla antigen class 2; antibody response; hla antigen class 1; graft versus host reaction; cross reaction; bone marrow transplantation; dna determination; hla antigens; human; priority journal; isoantibodies
Journal Title: New England Journal of Medicine
Volume: 329
Issue: 5
ISSN: 0028-4793
Publisher: Massachusetts Medical Society  
Date Published: 1993-07-29
Start Page: 362
End Page: 363
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027214098&doi=10.1056%2fNEJM199307293290516&partnerID=40&md5=68446d96b9731c2af83b3551bbfcb119
Notes: For full correspondence, see PMID: 8321273, DOI: 10.1056/nejm199307293290516 -- For original publication, see PMID: 8429851, DOI: 10.1056/NEJM199303043280901 -- Source: Scopus