Catenins as mediators of the cytoplasmic functions of cadherins Conference Paper
| Authors: | Gumbiner, B. M.; McCrea, P. D. |
| Title: | Catenins as mediators of the cytoplasmic functions of cadherins |
| Conference Title: | Keystone Meeting on Epithelial and Neuronal Cell Polarity and Differentiation |
| Abstract: | The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. α-Catenin is related to vinculin and seems to be required for the interaction of cadherins with the actin cytoskeleton. β-Catenin is homologous to armadillo, a segment polarity gene in Drosophila that participates in developmental signaling. Recent findings indicate that β-catenin also participates in developmental signaling and embryonic patterning in Xenopus laevis. At least a portion of the electrophoretic band migrating at the position of γ-catenin consists of plakoglobin, a desmosomal and zonula adherens protein that has high sequence similarity to β-catenin and armadillo. The catenins may be involved in the regulation of cadherin function during tissue morphogenesis and tumorigenesis. |
| Keywords: | signal transduction; review; nonhuman; conference paper; animal; animals; actin; cell function; biological model; models, biological; protein protein interaction; cell protein; drosophila; embryo development; physiology; transactivator protein; cytoplasm; binding protein; cell polarity; trans-activators; sequence homology; protein electrophoresis; beta catenin; cadherin; cell adhesion; cadherins; cytoskeleton; ctnnb1 protein, human; cytoskeleton protein; cytoskeletal proteins; xenopus laevis; adhesion; mediator; alpha catenin; plakoglobin; desmosome; catenin; desmoplakin; desmoplakins; gamma catenin; desmosomes; humans; human; priority journal; ctnna1 protein, human; jup protein, human |
| Journal Title | Journal of Cell Science |
| Volume: | 106 |
| Issue: | Suppl. 17 |
| Conference Dates: | 1993 Feb 4-10 |
| Conference Location: | Tamarron, CO |
| ISBN: | 0021-9533 |
| Publisher: | Company of Biologists |
| Date Published: | 1993-12-01 |
| Start Page: | 155 |
| End Page: | 158 |
| Language: | English |
| PUBMED: | 8144692 |
| PROVIDER: | scopus |
| DOI: | 10.1242/jcs.1993.Supplement_17.22 |
| DOI/URL: | |
| Notes: | Source: Scopus |
