Proliferation and differentiation biomarkers in colorectal mucosa and their application to chemoprevention studies Journal Article
| Authors: | Scalmati, A.; Lipkin, M. |
| Article Title: | Proliferation and differentiation biomarkers in colorectal mucosa and their application to chemoprevention studies |
| Abstract: | Colorectal cancer is one of the leading causes of morbidity and mortality in Western countries. Because its prognosis is relatively unaffected by improvements in surgery and chemotherapy, increasing interest has recently been directed toward chemoprevention. Intermediate biomarkers of abnormal cell proliferation, differentiation, and gene expression have recently been identified and have served to measure effects of chemopreventive agents in rodent models and in short-term human clinical trials. Alterations in cell proliferation and differentiation have been found in preneoplastic diseases and in normal-appearing colorectal mucosa of patients at increased risk for malignancy. Several techniques are available for measuring these alterations, and standardization and comparison of different methods are underway to assess the utility of various intermediate biomarkers in chemoprevention studies. |
| Keywords: | cancer risk; conference paper; colorectal cancer; cell proliferation; biological marker; chemoprophylaxis; gene expression; tumor differentiation; calcium; cell differentiation; tumor marker; oncogene; omega 3 fatty acid; alpha tocopherol; ascorbic acid; rodentia; tumor growth; retinol; beta carotene; cytoskeleton protein; intestine mucosa; mucin; lectin; precancer; lectin binding; triticum aestivum; human; wheat bran; blood group antigen |
| Journal Title: | Environmental Health Perspectives |
| Volume: | 99 |
| ISSN: | 0091-6765 |
| Publisher: | US Department of Health and Human Services |
| Date Published: | 1993-03-01 |
| Start Page: | 169 |
| End Page: | 173 |
| Language: | English |
| DOI: | 10.1289/ehp.9399169 |
| PUBMED: | 8319616 |
| PROVIDER: | scopus |
| PMCID: | PMC1567025 |
| DOI/URL: | |
| Notes: | Source: Scopus |
