Strategies for intervention with chemopreventive agents Conference Paper
| Author: | Lipkin, M. |
| Title: | Strategies for intervention with chemopreventive agents |
| Conference Title: | National Cancer Institute Workshop on Genetic Screening for Colorectal Cancer |
| Abstract: | Different mechanisms of activity have led to the development of a wide variety of intermediate biomarkers to measure the efficacy of chemopreventive agents. Chemopreventive agents are now being used in pre-clinical models that have targeted mutations or normal cells. Based on pre-clinical findings, clinical chemoprevention studies have progressed to measure the possible modulation of dysplastic lesions, including adenomas. Human studies are best carried out where the study design matches the known activity of the agents on cells in early, mid-or late stages of abnormal cellular development, previously determined in pre-clinical studies. |
| Keywords: | mutation; nonhuman; conference paper; animals; cancer prevention; chemoprophylaxis; tumor markers, biological; colonic neoplasms; calcium; drug evaluation, preclinical; diet; adenoma; eflornithine; nonsteroid antiinflammatory agent; anticarcinogenic agents; vitamin d; tamoxifen; flavonoid; omega 3 fatty acid; antioxidant; ascorbic acid; rodentia; indole derivative; beta carotene; retinoid; clinical trials; antiestrogen; phenol derivative; vitamin; tocopherol; isothiocyanic acid derivative; prasterone; cancer; humans; human; priority journal; protective agent; terpene derivative; flavone derivative; sulfur derivative |
| Journal Title | International Journal of Cancer |
| Volume: | 69 |
| Issue: | 1 |
| Conference Dates: | 1995 Apr 10-11 |
| Conference Location: | Bethesda, MD |
| ISBN: | 0020-7136 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1996-02-20 |
| Start Page: | 64 |
| End Page: | 67 |
| Language: | English |
| DOI: | 10.1002/(sici)1097-0215(19960220)69:1<64::aid-ijc17>3.0.co;2-k |
| PUBMED: | 8600066 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 22 November 2017 -- Source: Scopus |
