Acute promyelocytic leukemia Journal Article
| Authors: | Warrell, R. P. Jr; de Thé, H.; Wang, Z. Y.; Degos, L. |
| Article Title: | Acute promyelocytic leukemia |
| Abstract: | Discoveries in cancer research are rarely so exceptional that they both cause immediate changes in the treatment of patients and dramatically advance our understanding of the mechanisms underlying the disease. However, observations of the striking efficacy of all-trans-retinoic acid (tretinoin) in the treatment of patients with acute promyelocytic leukemia, followed closely by the discovery of a specific molecular genetic abnormality in a retinoid receptor, have greatly expanded scientific insight about leukemogenesis and have radically altered treatment strategies in this illness. The observation of tumor cells undergoing maturation as a patient enters remission has also provided a remarkable demonstration of drug-induced... © 1993, Massachusetts Medical Society. All rights reserved. |
| Keywords: | review; interferon; skin toxicity; tumor differentiation; bone pain; hypercalcemia; antineoplastic activity; cancer research; cancer resistance; arthralgia; cancer genetics; leukemia, promyelocytic, acute; drug mechanism; acute myeloblastic leukemia; remission induction; glucocorticoid; headache; sex hormone; rna, neoplasm; leukocytosis; retinoic acid; hypertriglyceridemia; butyric acid; teratogenesis; tretinoin; colecalciferol; nose congestion; colony stimulating factor; hexamethylenebisacetamide; human; priority journal; brain pseudotumor; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | New England Journal of Medicine |
| Volume: | 329 |
| Issue: | 3 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 1993-07-15 |
| Start Page: | 177 |
| End Page: | 189 |
| Language: | English |
| DOI: | 10.1056/nejm199307153290307 |
| PUBMED: | 8515790 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 March 2019 -- Source: Scopus |
