Diagnosis, staging, and surgical treatment of malignant pleural mesothelioma Journal Article
| Authors: | Kent, M.; Rice, D.; Flores, R. |
| Article Title: | Diagnosis, staging, and surgical treatment of malignant pleural mesothelioma |
| Abstract: | The clinical presentation of malignant pleural mesothelioma (MPM) is nonspecific. The process to obtain the correct diagnosis can be challenging and requires a high index of suspicion. Once the diagnosis is made, there is no universally accepted standard of care and treatment decisions are strongly influenced by physician bias. Physicians who see few numbers of patients tend to treat based on symptoms alone by drainage of the pleural effusion and talc pleurodesis, while physicians at several tertiary referral centers tend to take an aggressive multimodality approach incorporating surgical resection, chemotherapy, and radiation. The primary goal of surgery in this setting is the resection of all gross disease. The choice of operation, extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D), depends on disease stage, pulmonary function, philosophy of the treating physician, and type of planned adjuvant therapy. © Current Medicine Group LLC 2008. |
| Keywords: | cancer survival; clinical feature; clinical trial; histopathology; intensity modulated radiation therapy; cisplatin; drug efficacy; multimodality cancer therapy; unspecified side effect; gemcitabine; cancer adjuvant therapy; cancer radiotherapy; combined modality therapy; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; lymph node metastasis; antineoplastic agent; lymph node dissection; neoplasm staging; diagnostic accuracy; medical decision making; electron microscopy; computer assisted tomography; multiple cycle treatment; lung resection; pneumonectomy; carcinoembryonic antigen; tumor differentiation; tomography, x-ray computed; time factors; drug dose escalation; lung adenocarcinoma; drug response; positron-emission tomography; neoplasm metastasis; pleura mesothelioma; mesothelioma; brachytherapy; medical oncology; pleura effusion; external beam radiotherapy; hyperthermic therapy; cancer classification; cytokeratin; mitomycin; photodynamic therapy; pemetrexed; pleurectomy; thorax drainage; pleura; pleural neoplasms; patient referral; calretinin; vimentin; cancer gene therapy; pleurodesis; pleura biopsy; methoxsalen |
| Journal Title: | Current Treatment Options in Oncology |
| Volume: | 9 |
| Issue: | 2-3 |
| ISSN: | 1527-2729 |
| Publisher: | Springer |
| Date Published: | 2008-01-01 |
| Start Page: | 158 |
| End Page: | 170 |
| Language: | English |
| DOI: | 10.1007/s11864-008-0070-4 |
| PUBMED: | 18758965 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: CTOOB" - "Source: Scopus" |
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