Clinical and dermoscopic features of cutaneous BAP1-inactivated melanocytic tumors: Results of a multicenter case-control study by the International Dermoscopy Society Journal Article
| Authors: | Yélamos, O.; Navarrete-Dechent, C.; Marchetti, M. A.; Rogers, T.; Apalla, Z.; Bahadoran, P.; Blázquez-Sánchez, N.; Busam, K.; Carrera, C.; Dusza, S. W.; de la Fouchardière, A.; Ferrara, G.; Gerami, P.; Kittler, H.; Lallas, A.; Malvehy, J.; Millán-Cayetano, J. F.; Nelson, K. C.; Quan, V. L.; Puig, S.; Stevens, H.; Thomas, L.; Marghoob, A. A. |
| Article Title: | Clinical and dermoscopic features of cutaneous BAP1-inactivated melanocytic tumors: Results of a multicenter case-control study by the International Dermoscopy Society |
| Abstract: | Background: Multiple BRCA1-associated protein 1 (BAP1)-inactivated melanocytic tumors (BIMTs) have been associated with a familial cancer syndrome involving germline mutations in BAP1. Objectives: We sought to describe the clinical and dermoscopic features of BIMTs. Methods: This was a retrospective, multicenter, case-control study. Participating centers contributed clinical data, dermoscopic images, and histopathologic data of biopsy-proven BIMTs. We compared the dermoscopic features between BIMTs and control patients. Results: The dataset consisted of 48 BIMTs from 31 patients (22 women; median age 37 years) and 80 control patients. Eleven patients had a BAP1 germline mutation. Clinically, most BIMTs presented as pink, dome-shaped papules (n = 24). Dermoscopically, we identified 5 patterns: structureless pink-to-tan with irregular eccentric dots/globules (n = 14, 29.8%); structureless pink-to-tan with peripheral vessels (n = 10, 21.3%); structureless pink-to-tan (n = 7, 14.9%); a network with raised, structureless, pink-to-tan areas (n = 7, 14.9%); and globular pattern (n = 4, 8.5%). The structureless with eccentric dots/globules pattern and network with raised structureless areas pattern were only identified in BIMT and were more common in patients with BAP1 germline mutations (P < .0001 and P = .001, respectively). Limitations: Limitations included our small sample size, retrospective design, the absence of germline genetic testing in all patients, and inclusion bias toward more atypical-looking BIMTs. Conclusions: Dome-shaped papules with pink-to-tan structureless areas and peripheral irregular dots/globules or network should raise the clinical suspicion for BIMT. © 2018 American Academy of Dermatology, Inc. |
| Keywords: | melanoma; dermoscopy; bap1; wiesner nevus; atypical spitzoid tumor; bap1-inactivated melanocytic tumors |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 80 |
| Issue: | 6 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2019-06-01 |
| Start Page: | 1585 |
| End Page: | 1593 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2018.09.014 |
| PUBMED: | 30244062 |
| PROVIDER: | scopus |
| PMCID: | PMC6426687 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 June 2019 -- Source: Scopus |
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