Clinical and dermoscopic features associated with lichen planus-like keratoses that undergo skin biopsy: A single-center, observational study Journal Article
| Authors: | Liopyris, K.; Navarrete-Dechent, C.; Dusza, S. W.; Marghoob, A. A.; Deng, L.; Wilson, B. B.; Marchetti, M. A. |
| Article Title: | Clinical and dermoscopic features associated with lichen planus-like keratoses that undergo skin biopsy: A single-center, observational study |
| Abstract: | Background/Objectives: Lichen planus-like keratoses (LPLK) are benign skin lesions that can mimic malignancy; the clinical and dermoscopic features distinguishing lichen planus-like keratoses from skin tumors have not been extensively studied. The objective of this study was to identify dermoscopic features that may prevent unnecessary biopsies of lichen planus-like keratoses. Methods: Retrospective, single-center, observational study of biopsied skin lesions at a tertiary center. We compared 355 lichen planus-like keratoses to 118 non-lichen planus-like keratoses lesions with lichen planus-like keratosis in the differential diagnosis biopsied from August 1, 2015, to December 31, 2016. The investigators were blinded to the diagnosis of the lesions. Results: Lichen planus-like keratoses were most frequently non-pigmented (61.7%), truncal (52.1%), and on sun-damaged skin (69.6%); the majority occurred in Whites (95.5%) and females (62.8%). Dermoscopically, lichen planus-like keratoses were more likely than non-lichen planus-like keratoses to have scale (42.5% vs 31.4%, P = 0.03) and orange colour (8.2% vs 0.9%, P = 0.01). Among lesions with peppering (n = 76; 63 lichen planus-like keratoses and 13 non-lichen planus-like keratoses), coarse ± fine peppering (73% vs 38.5%, P = 0.02) and peppering as the only feature (34.9% vs 0%, P = 0.01) were associated with lichen planus-like keratoses. Conclusions: Lichen planus-like keratoses can be challenging to distinguish from benign and malignant skin tumors. The presence of dermoscopic scale and orange colour may aid in the recognition of lichen planus-like keratosis. Coarse peppering and the presence of peppering as the only dermoscopic feature may further aid the identification of pigmented lichen planus-like keratoses. © 2018 The Australasian College of Dermatologists |
| Keywords: | dermoscopy; blk; lichen planus-like keratosis; benign lichenoid keratosis; lichenoid keratosis; lplk |
| Journal Title: | Australasian Journal of Dermatology |
| Volume: | 60 |
| Issue: | 2 |
| ISSN: | 0004-8380 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2019-05-01 |
| Start Page: | e119 |
| End Page: | e126 |
| Language: | English |
| DOI: | 10.1111/ajd.12955 |
| PROVIDER: | scopus |
| PMCID: | PMC6520177 |
| PUBMED: | 30450536 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 June 2019 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work