Value of tumor size as a prognostic factor in metastatic colorectal cancer patients after chemotherapy: A population-based study Journal Article
| Authors: | Yan, Q.; Zhang, K.; Guo, K.; Liu, S.; Wasan, H. S.; Jin, H.; Yuan, L.; Feng, G.; Shen, F.; Shen, M.; Ma, S.; Ruan, S. |
| Article Title: | Value of tumor size as a prognostic factor in metastatic colorectal cancer patients after chemotherapy: A population-based study |
| Abstract: | Aim: To evaluate the relationship between tumor size and survival in metastatic colorectal cancer (mCRC) patients who received chemotherapy. Materials & methods: SEER database was accessed for eligible patients. Multivariate Cox regression analysis was performed to compare the effect of tumor size on overall survival (OS) and CRC-specific survival (CCSS). Results: Tumor size ≥5 cm was an independent risk factor for OS and CCSS in mCRC patients treated with chemotherapy. Tumor size <5 cm did not show a survival advantage in patients whose primary tumor site was rectosigmoid junction, while tumor size ≥5 cm was associated with poor OS and CCSS in left-and right-sided colorectal cancer. Conclusion: Tumor size ≥5 cm was associated with poor prognosis after receiving chemotherapy treatment and a risk factor for survival of mCRC. © 2019 Future Medicine Ltd. |
| Keywords: | chemotherapy; tumor size; metastatic colorectal cancer |
| Journal Title: | Future Oncology |
| Volume: | 15 |
| Issue: | 15 |
| ISSN: | 1479-6694 |
| Publisher: | Future Medicine |
| Date Published: | 2019-05-01 |
| Start Page: | 1745 |
| End Page: | 1758 |
| Language: | English |
| DOI: | 10.2217/fon-2018-0785 |
| PUBMED: | 31038364 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 June 2019 -- Source: Scopus |
