Shouts, whispers and the kiss of death: Directional secretion in T cells Journal Article
| Authors: | Huse, M.; Quann, E. J.; Davis, M. M. |
| Article Title: | Shouts, whispers and the kiss of death: Directional secretion in T cells |
| Abstract: | T cells use secreted soluble factors for highly specific intercellular communication and targeted cell killing. This specificity is achieved first through T cell receptor-mediated recognition of complexes of peptide and major histocompatibility complex displayed by appropriate antigen-presenting cells and then by the directed secretion of cytokines and lytic factors into the immunological synapse between the T cell and antigen-presenting cell. Studies have begun to probe the molecular basis for this synaptic secretion and have also shown that T cells release chemokines and certain inflammatory factors through a multidirectional pathway directed away from the synapse. Thus, the mode of secretion seems to be tailored to the intended function of the secreted molecule. |
| Keywords: | gene mutation; review; nonhuman; cd8 antigen; cd8+ t lymphocyte; t lymphocyte; t-lymphocytes; animals; interleukin 2; protein protein interaction; cd40 ligand; interleukin 10; interleukin 4; inflammation; inflammation mediators; b lymphocyte; t lymphocyte receptor; antigen presentation; lymphocyte activation; cellular immunity; transcription regulation; gamma interferon; messenger rna; antigen recognition; cd4+ t lymphocyte; cytotoxic t lymphocyte; cell polarity; perforin; cd4 antigen; cytokine release; microtubules; cell communication; actin polymerization; antigen presenting cell; antigen-presenting cells; protein kinase lck; protein kinase zap 70; microtubule organizing center; synaptotagmin; rac protein; tumor necrosis factor; immunopathogenesis; dynein adenosine triphosphatase; protein kinase c delta; calcium signaling; protein kinase fyn; calcium ion; major histocompatibility antigen; translation regulation; snare protein; rantes; lymphocyte function associated antigen 1; calmodulin; granzyme; macrophage inflammatory protein 1alpha; rab27a protein; syntaxin 1; vav protein; cell destruction; hemophagocytic lymphohistiocytosis; ocular albinism |
| Journal Title: | Nature Immunology |
| Volume: | 9 |
| Issue: | 10 |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-10-01 |
| Start Page: | 1105 |
| End Page: | 1111 |
| Language: | English |
| DOI: | 10.1038/ni.f.215 |
| PUBMED: | 18800163 |
| PROVIDER: | scopus |
| PMCID: | PMC2905669 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 44" - "Export Date: 17 November 2011" - "CODEN: NIAMC" - "Source: Scopus" |
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