Clinical pharmacology of cancer therapies in older adults Journal Article
| Authors: | Hurria, A.; Lichtman, S. M. |
| Article Title: | Clinical pharmacology of cancer therapies in older adults |
| Abstract: | This abbreviated review outlines the physiologic changes associated with aging, and examines how these changes may affect the pharmacokinetics and pharmacodynamics of anticancer therapies. We also provide an overview of studies that have been conducted evaluating the pharmacology of anticancer therapies in older adults, and issue a call for further research. © 2008 Cancer Research UK. |
| Keywords: | aged; aged, 80 and over; antibiotic agent; unclassified drug; clinical trial; neutropenia; cisplatin; doxorubicin; fluorouracil; area under the curve; side effect; unspecified side effect; antineoplastic agents; clinical trials as topic; capecitabine; paclitaxel; cytarabine; methotrexate; temozolomide; drug megadose; neurotoxicity; colorectal cancer; carboplatin; nephrotoxicity; breast cancer; bone marrow suppression; etoposide; leukopenia; lung non small cell cancer; mucosa inflammation; neuropathy; peripheral neuropathy; cyclophosphamide; furosemide; oncology; cancer therapy; docetaxel; fever; warfarin; drug clearance; mental disease; nausea and vomiting; short survey; glomerulus filtration rate; aging; folic acid; taxane derivative; drug half life; navelbine; oxaliplatin; mannitol; diabetic neuropathy; hematologic disease; pharmacokinetics; creatinine clearance; geriatrics; electrolyte disturbance; ototoxicity; older patient; nab paclitaxel; kidney dysfunction; kidney blood flow; geriatric oncology; gastrointestinal absorption; platinum clearance |
| Journal Title: | British Journal of Cancer |
| Volume: | 98 |
| Issue: | 3 |
| ISSN: | 0007-0920 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-02-12 |
| Start Page: | 517 |
| End Page: | 522 |
| Language: | English |
| DOI: | 10.1038/sj.bjc.6604201 |
| PUBMED: | 18256586 |
| PROVIDER: | scopus |
| PMCID: | PMC2243152 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 16" - "Export Date: 17 November 2011" - "CODEN: BJCAA" - "Source: Scopus" |
