History of bacillus Calmette-Guerin and bladder cancer: An immunotherapy success story Journal Article

  


Authors: Herr, H. W.; Morales, A.
Article Title: History of bacillus Calmette-Guerin and bladder cancer: An immunotherapy success story
Abstract: Purpose: We review how the bacillus Calmette-Guerin vaccine evolved to become standard therapy for superficial bladder cancer. Materials and Methods: We reviewed the historical literature describing the origin of the bacillus Calmette-Guerin vaccine as an anticancer agent and its singular success as the most effective immunotherapy used against a human neoplasm. Results: The association between tuberculosis and cancer, and the demonstration that bacillus Calmette-Guerin invoked immunological reactivity, inhibiting tumor growth in experimental animal models, led to clinical trials showing that intravesical bacillus Calmette-Guerin eradicated and prevented recurrence of superficial bladder tumors. Conclusions: For the last 3 decades bacillus Calmette-Guerin therapy has remained the most effective local therapy for superficial bladder cancer, an outstanding example of successful translational medicine in urology. © 2008 American Urological Association.
Keywords: nonhuman; disease association; bcg vaccine; cancer immunotherapy; melanoma; immunoreactivity; bladder cancer; urinary bladder neoplasms; thiotepa; acute lymphoblastic leukemia; history, 20th century; cancer inhibition; mycobacterium tuberculosis; immunotherapy; mycobacterium bovis; adjuvants, immunologic; history of medicine; delayed hypersensitivity; lung tuberculosis; portraits as topic
Journal Title: Journal of Urology
Volume: 179
Issue: 1
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 2008-01-01
Start Page: 53
End Page: 56
Language: English
DOI: 10.1016/j.juro.2007.08.122
PUBMED: 17997439
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-36749051886&partnerID=40&md5=5cbf5a01b23cd43965d9ca872b1c9f7a
Notes: --- - "Cited By (since 1996): 31" - "Export Date: 17 November 2011" - "CODEN: JOURA" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Albert Morales
    4 Morales
  2. Harry W Herr
    594 Herr
Related MSK Work