An analysis of the effect of statin use on the efficacy of bacillus calmette-guerin treatment for transitional cell carcinoma of the bladder Journal Article

  

Authors:	Berglund, R. K.; Savage, C. J.; Vora, K. C.; Kurta, J. M.; Cronin, A. M.
Article Title:	An analysis of the effect of statin use on the efficacy of bacillus calmette-guerin treatment for transitional cell carcinoma of the bladder
Abstract:	Purpose: Bacillus Calmette-Guerin is an effective immunotherapy for carcinoma in situ of the bladder and it reduces recurrence from resected papillary transitional cell carcinoma of the bladder. Many patients receiving bacillus Calmette-Guerin therapy are concurrently taking statin agents, which have known immunomodulatory properties and may alter the performance of bacillus Calmette-Guerin. Some data have suggested that patients taking a statin while on bacillus Calmette-Guerin therapy experience reduced clinical efficacy. Materials and Methods: We conducted a retrospective review of 952 consecutive patients from 1978 through 2006. Time to recurrence and progression to surgery were compared between those taking and those not taking a statin by Kaplan-Meier methods and multivariable Cox regression controlling for stage and grade. Results: There were 245 (26%) patients taking a statin before bacillus Calmette-Guerin therapy and 707 not on statin therapy (74%). A total of 796 patients had recurrence overall with 214 in the statin group and 582 in the other group. Median time to recurrence was similar between those who did and those who did not use a statin. On multivariable analysis statin use was not significantly associated with recurrence (hazard ratio 1.04; 95% CI 0.81, 1.34; p = 0.7) or progression to surgery (hazard ratio 0.77; 95% CI 0.52, 1.13; p = 0.17) after bacillus Calmette-Guerin therapy. Conclusions: This retrospective study in a large cohort of patients showed no statistically significant association between statin use and recurrence or progression to open surgery in patients treated with bacillus Calmette-Guerin for transitional cell carcinoma of the bladder. Based on these data patients should not be discouraged from taking statins while undergoing bacillus Calmette-Guerin treatment. © 2008 American Urological Association.
Keywords:	adult; controlled study; treatment outcome; aged; aged, 80 and over; middle aged; survival analysis; surgical technique; retrospective studies; major clinical study; cancer recurrence; cancer growth; cancer staging; follow up; neoplasm staging; analysis; cancer grading; bcg vaccine; cohort studies; neoplasm recurrence, local; proportional hazards models; drug effect; retrospective study; urinary bladder neoplasms; risk assessment; kaplan-meiers estimate; proportional hazards model; immunotherapy; drug therapy, combination; disease progression; reference values; carcinoma; mycobacterium bovis; immunomodulation; multivariate analysis; physical examination; kaplan meier method; cancer control; carcinoma, transitional cell; administration, intravesical; bladder carcinoma; transitional cell carcinoma; hydroxymethylglutaryl coenzyme a reductase inhibitor; transitional cell; hydroxymethylglutaryl-coa reductase inhibitors; urine cytology; evaluation studies as topic
Journal Title:	Journal of Urology
Volume:	180
Issue:	4
ISSN:	0022-5347
Publisher:	Elsevier Science, Inc.
Date Published:	2008-10-01
Start Page:	1297
End Page:	1300
Language:	English
DOI:	10.1016/j.juro.2008.06.034
PUBMED:	18707737
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-50949104246&partnerID=40&md5=f1ba68c2a294971343ea7872e562b2ea
Notes:	--- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: JOURA" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/14044