Expanding therapeutic opportunities for hematopoietic stem cell transplantation: T cell depletion as a model for the targeted allograft Journal Article


Authors: Cho, C.; Perales, M. A.
Article Title: Expanding therapeutic opportunities for hematopoietic stem cell transplantation: T cell depletion as a model for the targeted allograft
Abstract: Allogeneic hematopoietic cell transplantation is a fundamental part of the treatment of hematologic malignancies and marrow failure syndromes, but complications including graft-versus-host disease, prolonged immune deficiency and infection, and organ toxicities, as well as relapse, remain obstacles to improved overall survival. As the cellular characteristics of the allograft can exert significant impact on outcomes, the development of more strategically designed grafts represents a rich area for therapeutic intervention. We describe the use of ex vivo T cell-depleted grafts as a model for the targeted graft and review evolving knowledge and approaches for further refinement of allografts to improve patient outcomes.
Keywords: survival; t cell depletion; adoptive immunotherapy; clinical-trials; versus-host-disease; high-risk; myeloid-leukemia; disease; bone-marrow-transplantation; immune reconstitution; acute myelogenous leukemia; acute; allogeneic hematopoietic cell transplantation; graft-versus-host; cytomegalovirus-infection; predicts improved; comparative outcomes
Journal Title: Annual Review of Medicine
Volume: 70
ISSN: 0066-4219
Publisher: Annual Reviews  
Date Published: 2019-01-01
Start Page: 381
End Page: 393
Language: English
ACCESSION: WOS:000460209700026
PROVIDER: wos
PUBMED: 30359171
DOI: 10.1146/annurev-med-120617-041210
Notes: Review; Book Chapter -- Source: Wos
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MSK Authors
  1. Miguel-Angel Perales
    378 Perales
  2. Christina Cho
    38 Cho