Capitalizing on cancer replication stress by preventing PAR chain turnover: A new type of synthetic lethality Editorial
| Authors: | McDermott, N.; Buechelmaier, E. S.; Powell, S. N. |
| Title: | Capitalizing on cancer replication stress by preventing PAR chain turnover: A new type of synthetic lethality |
| Abstract: | Tumors resistant to PARP inhibitors frequently show signs of replication stress, with hyper-activated PARP. In this issue of Cancer Cell, Pillay et al. demonstrate that inhibiting PAR-chain turnover results in cell-cycle arrest, which is cytotoxic when combined with cell-cycle checkpoint inhibition and constitutes a novel cancer therapy. © 2019 Elsevier Inc. |
| Keywords: | unclassified drug; dna replication; homologous recombination; cell cycle s phase; enzyme inhibition; cytotoxicity; enzyme activity; cell cycle arrest; short survey; cell cycle checkpoint; dna damage response; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; histone h2ax; single stranded dna break; gamma histone h2ax; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 2; poly(adenosine diphosphate ribose); g2 phase cell cycle checkpoint; human; priority journal; glycosidase; malignant neoplasm; glycosidase inhibitor; pdd 0001627; poly(adenosine diphosphate ribose)glycosidase |
| Journal Title: | Cancer Cell |
| Volume: | 35 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2019-03-18 |
| Start Page: | 344 |
| End Page: | 346 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2019.02.011 |
| PUBMED: | 30889377 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
