Palbociclib: An evidence-based review of its potential in the treatment of breast cancer Journal Article
| Authors: | Cadoo, K. A.; Gucalp, A.; Traina, T. A. |
| Article Title: | Palbociclib: An evidence-based review of its potential in the treatment of breast cancer |
| Abstract: | Cellular proliferation, growth, and division following DNA (deoxyribonucleic acid) damage are tightly controlled by the cell-cycle regulatory machinery. This machinery includes cyclin-dependent kinases (CDKs) which complex with their cyclin partners, allowing the cell cycle to progress. The cell-cycle regulatory process plays a critical role in oncogenesis and in the development of therapeutic resistance; it is frequently disrupted in breast cancer, providing a rational target for therapeutic development. Palbociclib is a potent and selective inhibitor of CDK4 and -6 with significant activity in breast cancer models. Furthermore, it has been shown to significantly prolong progression-free survival when combined with letrozole in the management of estrogen receptor-positive metastatic breast cancer. In this article we review the cell cycle and its regulatory processes, their role in breast cancer, and the rationale for CDK inhibition in this disease. We describe the preclinical and clinical data relating to the activity of palbociclib in breast cancer and the plans for the future development of this agent. © 2014 Cadoo et al. |
| Keywords: | cyclin-dependent kinases; cdk4/6 inhibition; cell-cycle regulation |
| Journal Title: | Breast Cancer: Targets and Therapy |
| Volume: | 6 |
| ISSN: | 1179-1314 |
| Publisher: | Dove Medical Press Ltd |
| Date Published: | 2014-08-04 |
| Start Page: | 123 |
| End Page: | 133 |
| Language: | English |
| DOI: | 10.2147/bctt.s46725 |
| PROVIDER: | scopus |
| PUBMED: | 25177151 |
| PMCID: | PMC4128689 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2014 -- Source: Scopus |
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