Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies Journal Article
| Authors: | Condom, E.; Vidal, A.; Rota, R.; Graus, F.; Dalmau, J.; Ferrer, I. |
| Article Title: | Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies |
| Abstract: | Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudoobstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC. © 1993 Springer-Verlag. |
| Keywords: | adult; case report; lung neoplasms; lung small cell cancer; antigen; immunocytochemistry; nerve fiber; immunoblotting; autopsy; autoantibody; paraneoplastic syndrome; neurologic disease; nerve cell; antibodies, neoplasm; antibody titer; small-cell lung cancer; carcinoma, small cell; middle age; paraneoplastic syndromes; pseudo-obstruction; myenteric plexus; human; male; priority journal; article; support, non-u.s. gov't; hu antigen/antibody; paraneoplastic encephalomyelitis/sensory neuronopathy; visceral neuronopathy; intestine pseudoobstruction; intestinal pseudo-obstruction |
| Journal Title: | Virchows Archiv |
| Volume: | 423 |
| Issue: | 6 |
| ISSN: | 0945-6317 |
| Publisher: | Springer |
| Date Published: | 1993-11-01 |
| Start Page: | 507 |
| End Page: | 511 |
| Language: | English |
| DOI: | 10.1007/bf01606543 |
| PUBMED: | 8291223 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
