Abstract: |
It has become evident that a recently defined sphingomyelin metabolic pathway can function in signal transduction. Ceramide, generated by sphingomyelin hydrolysis, plays a role as second messenger and stimulates a membranebound serine/threonine kinase termed ceramide-activated protein kinase. This pathway appears to mediate signal transduction for tumor necrosis factor-a. It is presumed that other cellsurface receptors may utilize this pathway for signalling. © 1993, FCCA(Forum: Carbohydrates Coming of Age). All rights reserved. |