Signal transduction through the sphingomyelin pathway Journal Article
| Author: | Kolesnick, R. |
| Article Title: | Signal transduction through the sphingomyelin pathway |
| Abstract: | The sphingomyelin pathway is a new signal transduction system initiated by hydrolysis of palsma membrane sphingomyelin to ceramide by the actin of a neutral sphingomyelinase. Ceramide serine/threonine protein kinase termed ceramide-activated protein kinase. This kinase belongs to a family of proline-directed protein kinases that recognize substrates containing the minimal motif, X-Thr/Ser-Pro-X, where the phosphoacceptor site is followed on the carboxyl terminus by a proline residue and X may be any amino acid. Three lines of evidence, rapid kinetics of activation of the sphingomyelin pathway by tumor necrosis factor (TNF)α, the ability of cell-permeable ceramide analogs to bypass receptor activation and mimic the effect of TNFα, and reconstitution of this cascade in a cell-free system, support the concept that the sphingomyelin pathway serves to signal TNFα-induced monocytic differentiation. Hence, the sphingomyelin pathway may represent a signaling system analogous to more well-defined systems such as the cyclic adenosine monophosphate and phosphoinositide pathways. © 1994 Humana Press Inc. |
| Keywords: | signal transduction; protein phosphorylation; human cell; nonhuman; conference paper; animal cell; animal; protein kinases; epidermal growth factor receptor; cell differentiation; protein serine threonine kinase; amino acid sequence; molecular sequence data; tumor necrosis factor alpha; gamma interferon; protein-serine-threonine kinases; substrate specificity; cell membrane; cyclic amp; monocyte; monocytes; sphingosine; hydrolysis; diacylglycerol; phorbol esters; phorbol ester; tumor necrosis factor; ceramide; sphingomyelin phosphodiesterase; ceramide derivative; sphingomyelin; second messenger; phosphatidylinositide; sphingomyelins; phospholipase c; ceramide kinase; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; diacylglycerols |
| Journal Title: | Molecular and Chemical Neuropathology |
| Volume: | 21 |
| Issue: | 2-3 |
| ISSN: | 1044-7393 |
| Publisher: | Humana Press Inc |
| Date Published: | 1994-02-01 |
| Start Page: | 287 |
| End Page: | 297 |
| Language: | English |
| DOI: | 10.1007/bf02815356 |
| PROVIDER: | scopus |
| PUBMED: | 8086039 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: MCHNE C2 -- Source: Scopus |
