Low-dose-rate irradiation of rat embryo cells containing the Ha-ras oncogene Journal Article
| Authors: | Ong, A.; Li, W. X.; Ling, C. C. |
| Article Title: | Low-dose-rate irradiation of rat embryo cells containing the Ha-ras oncogene |
| Abstract: | Rat embryo cells and derived transfectants containing the Ha-ras oncogenes were irradiated with 60Co γ rays at dose rates of 0.72, 0.066, 0.035, and 0.018 Gy/min. The measured dose response of cell survival shows that the oncogene-containing cells exhibit higher survival levels at all doses than the parental cells at every dose rate. The response of the cells containing the ras oncogene also became dose-rate independent at a higher dose rate, perhaps indicative of a greater repair capability relative to that of the primary cells. |
| Keywords: | dose response; nonhuman; reproducibility; animal cell; animal; cell survival; embryo; transfection; radiation response; dose-response relationship, radiation; animalia; oncogene; rat; radiosensitivity; pregnancy; rats; genes, ras; cobalt radioisotopes; low energy radiation; cell activity; cell killing; embryo cell; northern blotting; rats, inbred f344; southern blotting; gamma rays; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s. |
| Journal Title: | Radiation Research |
| Volume: | 134 |
| Issue: | 2 |
| ISSN: | 0033-7587 |
| Publisher: | Radiation Research Society |
| Date Published: | 1993-05-01 |
| Start Page: | 251 |
| End Page: | 255 |
| Language: | English |
| DOI: | 10.2307/3578467 |
| PUBMED: | 8488259 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
