Antibody to a mutagenic peptide of herpes simplex virus in young adult patients with cancer of the head and neck Journal Article
| Authors: | Das, C. M.; Schantz, S. P.; Shillitoe, E. J. |
| Article Title: | Antibody to a mutagenic peptide of herpes simplex virus in young adult patients with cancer of the head and neck |
| Abstract: | Cancer of the head and neck has been associated with herpes simplex virus type-1 by serologic studies that have used virus particles or complex mixtures of viral proteins as antigens. Recently a peptide was found to be encoded by the transforming region of the virus that is mutagenic and is postulated to be involved in cell transformation. Sera from young adult patients with head and neck cancer and from control subjects were examined for the presence of antibody to this peptide with the use of an enzyme-linked immunosorbent assay. Antibody to the peptide was detected in many sera and showed a significant correlation with antibody to the virus in sera from control subjects. Antipeptide antibodies were largely of the IgM isotype, and patients had significantly higher levels of antibody than control subjects. This study is consistent with an association between HSV-1 and head and neck cancer and suggests that this viral peptide should be investigated further for its role in carcinogenesis. © 1993. |
| Keywords: | adult; clinical article; controlled study; squamous cell carcinoma; nonhuman; animal cell; animal; smoking; enzyme linked immunosorbent assay; head and neck neoplasms; simplexvirus; protein induction; high risk population; mutation rate; enzyme-linked immunosorbent assay; antibody detection; malignant transformation; herpes simplex virus; mouth carcinoma; mouth neoplasms; immunoglobulin g antibody; antibody production; cell transformation, viral; vero cell; vero cells; protein antibody; virus protein; viral proteins; virus carcinogenesis; immunoglobulin m antibody; immunoglobulin m; mutagens; carcinogens; synthetic peptide; antibodies, viral; antigens, viral; immunoglobulin a antibody; virus cultivation; human; male; female; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Oral Surgery, Oral Medicine, Oral Pathology |
| Volume: | 75 |
| Issue: | 5 |
| ISSN: | 0030-4220 |
| Publisher: | Elsevier BV |
| Date Published: | 1993-05-01 |
| Start Page: | 610 |
| End Page: | 614 |
| Language: | English |
| DOI: | 10.1016/0030-4220(93)90235-v |
| PUBMED: | 8387664 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
