Taxol plus recombinant human granulocyte-colony stimulating factor as initial and as salvage chemotherapy for metastatic breast cancer: A preliminary report Journal Article
| Authors: | Seidman, A. D.; Reichman, B. S.; Crown, J. P.; Yao, T. J.; Heelan, R.; Hakes, T. B.; Lebwohl, D. E.; Gilewski, T. A.; Surbone, A.; Currie, V.; Hudis, C. A.; Klecker, R.; Jamis-Dow, C.; Collins, J.; Quinlivan, S.; Berkery, R.; Toomasi, F.; Canetta, R.; Norton, L. |
| Article Title: | Taxol plus recombinant human granulocyte-colony stimulating factor as initial and as salvage chemotherapy for metastatic breast cancer: A preliminary report |
| Abstract: | Twenty-eight patients received Taxol as their first chemotherapy for stage IV breast cancer. An additional 51 patients with extensive prior exposure to other chemotherapeutic agents received Taxol as salvage therapy. We found significant activity for the drug in both situations, as well as a strong clinical suggestion of non-cross-resistance with doxorubicin. An excellent response in previously irradiated skin was noted in one case. The routine use of recombinant human granulocyte-colony stimulating factor seemed to ameliorate some of the dose-limiting toxicity of neutropenia. Other toxicity was mild to moderate in most cases. With further development, Taxol should play a significant role in the systemic management of breast cancer. |
| Keywords: | adult; aged; middle aged; salvage therapy; paclitaxel; antineoplastic agent; metastasis; antineoplastic combined chemotherapy protocols; breast neoplasms; breast tumor; recombinant proteins; recombinant protein; neoplasm metastasis; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; humans; human; female; article |
| Journal Title: | Journal of the National Cancer Institute - Monographs |
| Issue: | 15 |
| ISSN: | 1052-6773 |
| Publisher: | Oxford University Press |
| Date Published: | 1993-01-01 |
| Start Page: | 171 |
| End Page: | 175 |
| Language: | English |
| PUBMED: | 7517153 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
