Taxol (paclitaxel) plus recombinant human granulocyte colony-stimulating factor in the treatment of metastatic breast cancer Conference Paper
| Authors: | Seidman, A. D.; Norton, L.; Reichman, B. S.; Crown, J. P. A.; Yao, T. J.; Hakes, T. B.; Lebwohl, D. E.; Gilewski, T. A.; Hudis, C. A.; Surbone, A.; Currie, V.; Klecker, R.; Jamis-Dow, C.; Collins, J.; Marks, L.; Quinlivan, S.; Berkery, R.; Canetta, R.; Onetlo, N.; Arbuck, S. |
| Title: | Taxol (paclitaxel) plus recombinant human granulocyte colony-stimulating factor in the treatment of metastatic breast cancer |
| Conference Title: | Symposium on New Directions in Anti-Cancer Chemotherapy |
| Abstract: | We treated 28 patients who had no prior chemotherapy for stage IV breast cancer and 51 patients with extensive prior exposure to other chemotherapeutic agents with a 24-hour infusion of Taxol (paclitaxel) as a single agent. Prophylactic recombinant human granulocyte colony-stimulating factor was administered routinely to ameliorate the anticipated dose-limiting toxicity of neutropenia. Nonhematologic toxicity was mild to moderate in most cases. Taxol was more active in patients with chemotherapy-naive stage IV disease, but activity was also observed in extensively treated patients as well. There is a strong clinical suggestion of at least partial noncross-resistance with doxorubicin. Taxol is a very promising agent for the treatment of metastatic breast cancer; its optimal application in this disease will be the subject of future trials. © 1994 S. Karger AG, Basel. |
| Keywords: | adult; aged; middle aged; major clinical study; prednisone; fatigue; neutropenia; salvage therapy; doxorubicin; fluorouracil; conference paper; paclitaxel; methotrexate; cancer staging; neoplasm staging; breast cancer; leukopenia; mucosa inflammation; nausea; stomatitis; thrombocytopenia; antineoplastic combined chemotherapy protocols; myalgia; peripheral neuropathy; cyclophosphamide; dexamethasone; vincristine; drug resistance; breast neoplasms; arthralgia; drug hypersensitivity; fever; mitoxantrone; neoplasm metastasis; muscle weakness; erythema; remission induction; pancytopenia; recombinant granulocyte colony stimulating factor; anthracycline; breast metastasis; alopecia; infusions, intravenous; granulocyte colony-stimulating factor; intravenous drug administration; oral drug administration; diphenhydramine; g-csf; cimetidine; taxol; anthraquinone; cremophor; subcutaneous drug administration; injection pain; humans; human; female; priority journal |
| Journal Title | Oncology (Switzerland) |
| Volume: | 51 |
| Issue: | Suppl. 1 |
| Conference Dates: | 1993 Feb |
| Conference Location: | Paris, France |
| ISBN: | 0030-2414 |
| Publisher: | S. Karger AG |
| Date Published: | 1994-10-01 |
| Start Page: | 33 |
| End Page: | 39 |
| Language: | English |
| DOI: | 10.1159/000227414 |
| PROVIDER: | scopus |
| PUBMED: | 7526308 |
| DOI/URL: | |
| Notes: | (ISBN: 978-3-8055-6080-1) -- Export Date: 14 January 2019 -- Article -- Source: Scopus |
