Nuclear magnetic resonance structural studies of A · AT base triple alignments in intramolecular purine · purine · pyrimidine DNA triplexes in solution Journal Article
| Authors: | Radhakrishnan, I.; de los Santos, C.; Patel, D. J. |
| Article Title: | Nuclear magnetic resonance structural studies of A · AT base triple alignments in intramolecular purine · purine · pyrimidine DNA triplexes in solution |
| Abstract: | This study reports on an NMR characterization of an intramolecular purine · purine · pyrimidine (R · RY) triplex containing a, central A · AT triple in addition to G · GC and T · AT triples. Our studies establish an A(anti) · AT alignment with reversed Hoogsteen pairing stabilized by two N6H . . . N hydrogen bonds between adenine residues in the third strand and the purine strand of the duplex. This result, combined with our earlier demonstration of G(anti) · GC and T(anti) · AT pairing alignments, has provided a definitive experimental approach for differentiating between the base triple pairing possibilities proposed previously by Beal and Dervan for R · RY triplexes. © 1993 Academic Press Limited. |
| Keywords: | pyrimidines; dna; magnetic resonance spectroscopy; dna structure; hydrogen bonding; purines; nucleic acid conformation; nuclear magnetic resonance; nmr; nucleic acid base; priority journal; article; support, u.s. gov't, p.h.s.; deoxyribonucleotides; a · at triples; r · ry triplexes; triple helix |
| Journal Title: | Journal of Molecular Biology |
| Volume: | 234 |
| Issue: | 1 |
| ISSN: | 0022-2836 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 1993-11-05 |
| Start Page: | 188 |
| End Page: | 197 |
| Language: | English |
| DOI: | 10.1006/jmbi.1993.1573 |
| PUBMED: | 8230198 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
