A dose-ranging study of daily maintenance intravenous foscarnet therapy for cytomegalovirus retinitis in AIDS Journal Article
| Authors: | Jacobson, M. A.; Causey, D.; Polsky, B.; Hardy, D.; Chown, M.; Davis, R.; O'Donnell, J. J.; Kuppermann, B. D.; Heinemann, M. H.; Holland, G. N.; Mills, J.; Feinberg, J. E. |
| Article Title: | A dose-ranging study of daily maintenance intravenous foscarnet therapy for cytomegalovirus retinitis in AIDS |
| Abstract: | Thirty-two patients with AIDS and previously untreated cytomegalovirus retinitis completed an induction course of foscarnet, 60 mg/kg every 8 h for 14 days, had retinitis stabilize, and were then randomly assigned to receive foscarnet maintenance as either a 90- or 120-mg/kg/day infusion administered over 2 h. Median survival was 157 and 336 days for the 90- and 120-mg/kg/day groups, respectively (P <.001). In an independent, masked analysis of retinal photographs, median time to progression ofretinitis was 31 versus 95 days (P =.13). Daily intravenous foscarnet at a dose of 120 mg/kg (adjusted for renal function) resulted in significantly longer survival and tended to increase time to retinitis progression compared to the standard 90-mg/kg/day maintenance dose. Although a substantial increase in the risk of serious toxicity at the 120-mg/kg/day dose was not observed, the small sample size in this trial limited the power to detect differences that might be clinically important. © 1993 by The University of Chicago. |
| Keywords: | adolescent; adult; aged; survival rate; major clinical study; clinical feature; dose response; drug efficacy; drug safety; nephrotoxicity; risk assessment; fever; statistical analysis; drug response; patient compliance; retina detachment; pancytopenia; acquired immune deficiency syndrome; proteinuria; foscarnet; cytomegalovirus; injections, intravenous; hypocalcemia; oral drug administration; middle age; disease activity; aids-related opportunistic infections; retinitis; cytomegalovirus infections; human; male; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 168 |
| Issue: | 2 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 1993-08-01 |
| Start Page: | 444 |
| End Page: | 448 |
| Language: | English |
| DOI: | 10.1093/infdis/168.2.444 |
| PUBMED: | 8393058 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
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