Tumor-bearing animals contain suppressed antitumor effectors the function of which can be unmasked by IL-2 Journal Article
| Authors: | Salvadori, S.; Rosenthal, F. M.; Cronin, K.; Gansbacher, B.; Zier, K. S. |
| Article Title: | Tumor-bearing animals contain suppressed antitumor effectors the function of which can be unmasked by IL-2 |
| Abstract: | CMS5 fibrosarcoma cells were infected with retroviral constructs containing interleukin-2 (IL-2) cDNA and selected in G418. Parental tumor cells and those that produced IL-2 were injected in vivo. Whereas injection of parental tumor cells resulted in progressive tumor growth, those secreting high levels of IL-2 were rejected. Furthermore, the immunosuppression associated with inoculation of parental tumor cells was not seen. To understand the failure of mice to reject non-IL-2-secreting tumor cells, functional responses of spleen cells from immune and tumor-bearing mice were studied in vitro. As expected, immune spleen cells proliferated under a variety of conditions but were inhibited in the presence of parental tumor cells. Even spleen cells from tumor-bearing animals responded well in the absence of parental tumor cells or in the presence of parental tumor cells, if supplied with adequate levels of IL-2. These results suggest that both tumor-bearing and immune mice generate antitumor effectors but that the cells might be functionally suppressed because of their inability to secrete IL-2 after contact with parental tumor cells. © 1993, Raven Press, Ltd., New York. |
| Keywords: | nonhuman; conference paper; animal cell; mouse; animal; mice; interleukin 2; spleen; antineoplastic activity; tumor cells, cultured; mice, inbred balb c; cancer inhibition; antigen presentation; immune tolerance; fibrosarcoma; gene repression; growth regulation; graft rejection; neoplasm transplantation; tumor growth; antigens, cd28; interleukin-2; spleen cell; growth inhibition; rejection; sarcoma cell; suppression; antigen function; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; antitumor effectors; il-2-secreting tumor cells; parental tumor cells; t-lymphocytes, suppressor-effector |
| Journal Title: | Journal of Immunotherapy |
| Volume: | 14 |
| Issue: | 3 |
| ISSN: | 1524-9557 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1993-10-01 |
| Start Page: | 216 |
| End Page: | 220 |
| Language: | English |
| DOI: | 10.1097/00002371-199310000-00008 |
| PUBMED: | 8297903 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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14Cronin
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