Rationale for purging in autologous stem cell transplantation Journal Article
| Authors: | Gulati, S. C.; Acaba, L. |
| Article Title: | Rationale for purging in autologous stem cell transplantation |
| Abstract: | The success of autologous stem cell transplantation using bone marrow or peripheral blood stem cells depends not only on in vivo irradication of the disease by cytotoxic therapy but also on complete hematopoietic engraftment with no risk of relapse from the infused cells. Various methods are available for removing (purging) such contaminants. Purging techniques were developed by use of various in vitro models utilizing cell lines and fresh cancer cells. Once effective conditions were developed, they were advanced onto clinical trials. Various approaches for purging have been used. Subgroups of leukemia and lymphoma have now shown clinical benefit by the use of purged stem cells. Emphasis is now being placed on utilizing the information already obtained by the pre-clinical investigators on designing better clinical trials. © 1994, Mary Ann Liebert, Inc. All rights reserved. |
| Keywords: | cancer survival; controlled study; treatment outcome; leukemia; human cell; major clinical study; proto-oncogene proteins; clinical trial; disease course; antineoplastic agents; conference paper; combined modality therapy; antineoplastic agent; animals; controlled clinical trial; etoposide; neoplasm proteins; tumor markers, biological; cell line; cyclophosphamide; hematopoietic stem cell transplantation; cancer model; monoclonal antibody; whole body radiation; fluorescence in situ hybridization; lymphoma; hematopoietic stem cell; proto-oncogene proteins c-bcl-2; bone marrow rescue; cancer cell destruction; cell transplantation; autologous bone marrow transplantation; leukapheresis; bone marrow purging; bone marrow diseases; blood transfusion, autologous; 4 hydroperoxycyclophosphamide; humans; human; priority journal |
| Journal Title: | Journal of Hematotherapy and Stem Cell Research |
| Volume: | 2 |
| Issue: | 4 |
| ISSN: | 1525-8165 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 1993-01-01 |
| Start Page: | 467 |
| End Page: | 471 |
| Language: | English |
| DOI: | 10.1089/scd.1.1993.2.467 |
| PUBMED: | 7916249 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
