Clinical cardiotoxicity of 5‐fluorouracil Journal Article
| Authors: | Keefe, D. L.; Roistacher, N.; Pierri, M. K. |
| Article Title: | Clinical cardiotoxicity of 5‐fluorouracil |
| Abstract: | 5‐Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems. It also has cardiac toxicity, but this is perceived to be rare. During a 16‐month period from January 1990 through April 1991, approximately 910 patients were treated with 5‐fluorouracil. Five of these developed life‐threatening toxicity consistent with coronary artery spasm for an incidence of .55%. The acute events occurred on the third or fourth day of the 5‐day infusion and after the fourth intravenous bolus in the patient on bolus therapy. Each of the patients had ST elevation and ventricular arrhythmias, four had acute myocardial infarction, and two had cardiac arrests. In these cases and those previously reported, cardiac toxicity is consistent with drug‐ or metabolite‐mediated increases in coronary vasomotor tone and spasm, leading to the full spectrum of signs and symptoms of myocardial ischemia in susceptible individuals. 1993 American College of Clinical Pharmacology |
| Keywords: | adult; cancer chemotherapy; aged; major clinical study; case report; cisplatin; fluorouracil; methotrexate; neoplasms; carboplatin; time factors; heart infarction; cardiotoxicity; malignant neoplastic disease; creatine kinase; mitomycin; infusions, intravenous; electrocardiography; calcium channel blocking agent; electrocardiogram; heart ventricle arrhythmia; myocardial infarction; heart muscle ischemia; heart arrest; intravenous drug administration; heart diseases; middle age; diltiazem; st segment elevation; glyceryl trinitrate; coronary artery spasm; coronary vasospasm; nitric acid derivative; creatine kinase mb; arrhythmia; human; male; female; article; scintiangiography; isosorbide dinitrate |
| Journal Title: | Journal of Clinical Pharmacology |
| Volume: | 33 |
| Issue: | 11 |
| ISSN: | 0091-2700 |
| Publisher: | Sage Publications |
| Date Published: | 1993-11-01 |
| Start Page: | 1060 |
| End Page: | 1070 |
| Language: | English |
| DOI: | 10.1002/j.1552-4604.1993.tb01943.x |
| PUBMED: | 8300889 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
38Roistacher -
36Keefe -
16
Pierri
Related MSK Work