On the mechanism of DNA binding by nuclear hormone receptors: A structural and functional perspective Journal Article
| Authors: | Freedman, L. P.; Luisi, B. F. |
| Article Title: | On the mechanism of DNA binding by nuclear hormone receptors: A structural and functional perspective |
| Abstract: | The nuclear hormone receptor DNA‐binding domain consists of two zinc finger‐like modules whose amino acids are highly conserved among the members of the receptor superfamily. In this review, we describe the various genetic, biochemical, and structural experiments that have been carried out primarily for the DNA‐binding domains of the glucocorticoid and estrogen receptors. We describe how the structural and functional information have permitted us to predict properties of the DNA‐binding domains of other nuclear receptors. We postulate how receptors discriminate closely related response elements through sequence‐specific contacts and distinguish symmetry of target sites through protein‐protein interactions. This mechanism explains in part how the receptors regulate diverse sets of genes from a limited repertoire of core response elements. Lastly, we describe the stereochemical basis of nuclear receptor dysfunction in certain clinical disorders. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc. |
| Keywords: | dna-binding proteins; review; animal; genetic transcription; transcription regulation; amino acid sequence; molecular sequence data; transcription; base sequence; receptors, estrogen; cell nucleus; protein structure; hormone receptor; dna binding; steroid receptors; cell nucleus receptor; zinc finger protein; receptors, glucocorticoid; regulatory sequences, nucleic acid; zinc fingers; gene regulation; protein dimerization; human; priority journal; hormone responsive element; hormone response elements |
| Journal Title: | Journal of Cellular Biochemistry |
| Volume: | 51 |
| Issue: | 2 |
| ISSN: | 0730-2312 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1993-02-01 |
| Start Page: | 140 |
| End Page: | 150 |
| Language: | English |
| DOI: | 10.1002/jcb.240510205 |
| PUBMED: | 8440748 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
