| Abstract: |
The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse. © The Rockefeller University Press. |
| Keywords: |
nonhuman; protein conformation; animal cell; animal; microscopy, electron; protein degradation; gtp-binding proteins; structure-activity relationship; animalia; carrier proteins; recombinant proteins; protein transport; mutagenesis, site-directed; cell free system; guanosine triphosphate; golgi complex; cho cell; cho cells; adenosine diphosphate ribosylation factor; membrane vesicle; membrane fusion; cell-free system; golgi apparatus; adp-ribosylation factors; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; hamsters
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