Sentinel lymph node biopsy is successful and accurate in male breast carcinoma Journal Article
| Authors: | Flynn, L. W.; Park, J.; Patil, S. M.; Cody, H. S. 3rd; Port, E. R. |
| Article Title: | Sentinel lymph node biopsy is successful and accurate in male breast carcinoma |
| Abstract: | Background: Men and women with breast cancer have similar risks of morbidity related to axillary lymph node dissection (ALND). Sentinel lymph node (SLN) biopsy minimizes this risk. We report results from the largest series of SLN biopsies for male breast cancer and compare this experience with that of female counterparts treated concurrently. Study Design: The Memorial Sloan-Kettering Cancer Center SLN biopsy database showed that 7,315 SLN biopsy procedures were performed for primary breast cancer from September 1996 to July 2005. Of these, 78 (1.0%) procedures were performed in men. Followup data were obtained from medical record review. Results: SLN biopsy was successful in 76 of 78 (97%) patients. Negative SLNs were found in 39 of 76 (51%) patients. In 3 (8%) patients with negative SLNs, a positive non-SLN was found, identified by intraoperative palpation. Positive SLNs were found in 37 of 76 (49%) patients. In 22 of 37 (59%), node positivity was determined intraoperatively, prompting immediate ALND. In 15 of 37 (41%) patients with positive SLNs, node positivity was determined postoperatively. Of these 15, 9 (60%) underwent completion ALND. In the 2 of 78 (3%) patients with failed SLN biopsy procedures, ALND was performed and yielded positive nodes. At a median followup of 28 months (range 5 to 96 months), there were no axillary recurrences. Compared with their female counterparts, men with breast cancer had larger tumors and were more likely to have positive nodes. Conclusions: SLN biopsy is successful and accurate in male breast cancer patients. Although a larger proportion of men have positive nodes, for men with negative nodes, SLN biopsy may reduce morbidity related to ALND. © 2008 American College of Surgeons. |
| Keywords: | adolescent; adult; cancer chemotherapy; child; human tissue; aged; aged, 80 and over; middle aged; cancer surgery; major clinical study; histopathology; cancer patient; comparative study; postoperative care; follow up; antineoplastic agent; cancer diagnosis; lymph node dissection; lymphatic metastasis; neoplasm staging; diagnostic accuracy; lymphoscintigraphy; sentinel lymph node biopsy; tumor volume; tumor biopsy; breast neoplasms; medical record review; axillary lymph node; correlation coefficient; statistical significance; breast carcinoma; cancer epidemiology; biopsy technique; axilla; estrogen receptor; chi square test; breast surgery; peroperative care; breast biopsy; breast neoplasms, male |
| Journal Title: | Journal of the American College of Surgeons |
| Volume: | 206 |
| Issue: | 4 |
| ISSN: | 1072-7515 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2008-04-01 |
| Start Page: | 616 |
| End Page: | 621 |
| Language: | English |
| DOI: | 10.1016/j.jamcollsurg.2007.11.005 |
| PUBMED: | 18387465 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: JACSE" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work