A phase II trial of carboplatin in patients with advanced APUD tumors Journal Article
| Authors: | Saltz, L.; Lauwers, G.; Wiseberg, J.; Kelsen, D. |
| Article Title: | A phase II trial of carboplatin in patients with advanced APUD tumors |
| Abstract: | Background. Chemotherapy remains inadequate for patients with carcinoid tumors, islet cell tumors, and medullary carcinomas of the thyroid. Carboplatin has shown activity in oat cell carcinoma of the lung, another tumor of neuroectodermal origin. Methods. Forty‐two patients with advanced APUD tumors (20 carcinoid tumors, 9 islet cell carcinomas, 5 medullary carcinomas of the thyroid, and 9 neuroendocrine tumors of unknown primary site) were treated with carboplatin in a Phase II study. Results. Carboplatin was inactive in carcinoid and islet cell tumors, with 0 of 20 and 0 of 9 patients responding, respectively. Of the 41 total patients evaluable for response, only 2 (5%) achieved a partial response. Both of these responding patients had neuroendocrine tumors of unknown primary site. No complete responses were seen. Toxicities were those previously noted with carboplatin, with myelosuppression, particularly thrombocytopenia, being dose limiting. Conclusions. Carboplatin is inactive in carcinoid tumors and did not show evidence of activity in islet cell tumors. Further investigations are needed to identify active agents in the treatment of neuroendocrine malignancies. Copyright © 1993 American Cancer Society |
| Keywords: | adult; cancer survival; clinical article; aged; advanced cancer; neurotoxicity; carboplatin; liver toxicity; nephrotoxicity; phase 2 clinical trial; bone marrow suppression; antineoplastic activity; drug effect; carcinoma; neoplasm metastasis; carcinoid; dose calculation; carcinoid tumor; intravenous drug administration; neuroendocrine tumors; middle age; thyroid medullary carcinoma; adenoma, islet cell; human; male; female; priority journal; article; apud tumors; apudoma; oat cell carcinoma |
| Journal Title: | Cancer |
| Volume: | 72 |
| Issue: | 2 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1993-07-15 |
| Start Page: | 619 |
| End Page: | 622 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19930715)72:2<619::Aid-cncr2820720247>3.0.Co;2-e |
| PUBMED: | 8391382 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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