Immune‐mediated thrombocytopenia secondary to suramin Journal Article
| Authors: | Seidman, A. D.; Schwartz, M.; Reich, L.; Scher, H. I. |
| Article Title: | Immune‐mediated thrombocytopenia secondary to suramin |
| Abstract: | The authors report a case of suramin‐induced immune‐mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma. On withdrawal of suramin, the acute and severe thrombocytopenia did not respond initially to plasmapheresis; subsequently, it resolved promptly and dramatically during the administration of intravenous gamma globulin, also coinciding with a decline in suramin blood levels. Results of immunologic and coagulation studies are reported and clinical implications discussed. Copyright © 1993 American Cancer Society |
| Keywords: | adult; case report; drug withdrawal; disease association; phase 2 clinical trial; thrombocytopenia; immunoglobulin; plasmapheresis; kidney carcinoma; drug blood level; suramin; drug induced disease; intravenous drug administration; middle age; platelets; immune mediated injury; gamma globulin; human; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; immune thrombocytopenia |
| Journal Title: | Cancer |
| Volume: | 71 |
| Issue: | 3 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1993-02-01 |
| Start Page: | 851 |
| End Page: | 854 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19930201)71:3<851::Aid-cncr2820710331>3.0.Co;2-m |
| PUBMED: | 8431868 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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