Recent advances in the treatment of advanced colorectal cancer Journal Article
| Authors: | Kemeny, N.; Lokich, J. J.; Anderson, N.; Ahlgren, J. D. |
| Article Title: | Recent advances in the treatment of advanced colorectal cancer |
| Abstract: | The treatment of advanced colorectal cancer has improved in recent years. Prospective randomized trials comparing innovative therapies with the “standard” bolus dose of 5‐fluorouracil (5‐FU) found increased response rates after biochemical modification of the drug, infusion administration of 5‐FU, and direct intrahepatic arterial infusion. Although the impact on survival of these techniques has been minimal, it is possible that these innovative approaches provide an incremental survival advantage for certain subgroups of patients that may be the foundation for additional therapeutic improvements in the future. Copyright © 1993 American Cancer Society |
| Keywords: | cancer chemotherapy; cancer survival; hydroxyurea; fluorouracil; interferon; advanced cancer; cancer combination chemotherapy; cancer growth; dose response; drug potentiation; methotrexate; neoplasm staging; prospective studies; colorectal cancer; bolus injection; metastasis; phase 2 clinical trial; antineoplastic combined chemotherapy protocols; drug administration schedule; colorectal neoplasms; liver metastasis; randomized controlled trials; folinic acid; drug infusion; intraarterial drug administration; infusions, intra-arterial; tumor growth; floxuridine; leucovorin; aspartic acid; drug interactions; hepatic artery; intravenous drug administration; thymidine; phosphonoacetic acid; allopurinol; dipyridamole; drug mixture; sparfosic acid; biochemical modulation; human; priority journal; article; intrahepatic and systemic infusion |
| Journal Title: | Cancer |
| Volume: | 71 |
| Issue: | 1 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1993-01-01 |
| Start Page: | 9 |
| End Page: | 18 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19930101)71:1<9::Aid-cncr2820710104>3.0.Co;2-y |
| PUBMED: | 8416731 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
