Insulin-like growth factor-I unresponsiveness in an Efe Pygmy Journal Article
| Authors: | Geffner, M. E.; Bailey, R. C.; Bersch, N.; Vera, J. C.; Golde, D. W. |
| Article Title: | Insulin-like growth factor-I unresponsiveness in an Efe Pygmy |
| Abstract: | The cause of short stature in African Pygmies is unknown, but some evidence suggests that they are GH resistant. Since IGF-I mediates many actions of GH, we sought to determine if Pygmy tissue is responsive to IGF-I. We established HTLV-II-transformed cell lines from 1 Efe Pygmy, 1 African control, and 3 American controls, and quantified in vitro colony formation in response to IGF-I, GH, and insulin, and assessed IGF-I receptor binding. The Pygmy T-cell line showed no clonal responsiveness following stimulation with physiologic concentrations of IGF-I or any concentration of OH, but responded normally to insulin. IGF-I binding studies showed no binding to the Pygmy T-cell line with normal binding to control cells. The primary abnormality in this Pygmy T-cell line is IGF-I resistance at the receptor level with secondary OH resistance. © 1993 Academic Press, Inc. |
| Keywords: | adult; clinical article; controlled study; human cell; comparative study; lymphocyte proliferation; t-lymphocytes; drug resistance; growth hormone; short stature; receptor, igf type 1; kinetics; recombinant proteins; human growth hormone; cell line, transformed; insulin; somatomedin c; insulin-like growth factor i; cell transformation, viral; ethnic groups; human t-lymphotropic virus 2; human; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; democratic republic of the congo; negroid race |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 193 |
| Issue: | 3 |
| ISSN: | 0006-291X |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1993-06-30 |
| Start Page: | 1216 |
| End Page: | 1223 |
| Language: | English |
| DOI: | 10.1006/bbrc.1993.1755 |
| PUBMED: | 8323544 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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