Recent achievements in the development of radiolabeled monoclonal antibodies for diagnosis, therapy and biologic characterization of human tumors Journal Article

  


Authors: Larson, S. M.; Macapinlac, H. A.; Scott, A. M.; Divgi, C. R.
Article Title: Recent achievements in the development of radiolabeled monoclonal antibodies for diagnosis, therapy and biologic characterization of human tumors
Abstract: Human tumors express antigenic sites that can serve as targets for radiolabeled monoclonal antibodies for diagnosis, therapy and biologic characterization of human tumors in vivo. Over the last decade, nearly 200 clinical trials have been performed which demonstrate that tumors can be detected with excellent sensitivity and specificity. Tumors which are otherwise occult, particularly for colorectal (anti-CEA and anti-TAG-72 antibodies) and ovarian cancer (anti-TAG-72 and anti-HMFG), are detected in a significant fraction of problem patients. Therapy using radiolabeled antibodies has been effective in lymphomas, leukemias and neuroblastomas, and is beginning to show promise in other solid tumors. Biologic characterization of tumors is likely to become more and more important in the future as monoclonal antibodies against oncogene products, such as her-Zneu, are developed. Development of new antibody forms through genetic engineering techniques, and the continual evolution toward higher resolution imaging instruments, such as PET and SPECT, will lead to further clinical improvements in cancer detection. ©1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords: conference paper; positron emission tomography; technetium 99m; neoplasms; monoclonal antibody; antibodies, monoclonal; iodine 125; iodine 131; isotope labeling; iodine 124; radioimmunotherapy; fluorine 18; single photon emission computer tomography; indium 111; radioisotopes; radioimmunodetection; yttrium 90; iodine 123; immunoscintigraphy; copper 67; cancer; human; priority journal
Journal Title: Acta Oncologica
Volume: 32
Issue: 7-8
ISSN: 0284-186X
Publisher: Informa Healthcare  
Date Published: 1993-01-01
Start Page: 709
End Page: 715
Language: English
DOI: 10.3109/02841869309096125
PUBMED: 8305216
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027753244&doi=10.3109%2f02841869309096125&partnerID=40&md5=b445e7f6d6f43cbd30725c0ee35c8f26
Notes: Source: Scopus
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MSK Authors
  1. Chaitanya Divgi
    163 Divgi
  2. Homer Macapinlac
    106 Macapinlac
  3. Steven M Larson
    958 Larson
  4. Andrew M. Scott
    62 Scott
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