Influence of carboplatin infusion on osteosarcoma blood flow Journal Article
| Authors: | DiResta, G. R.; Aiken, S. W.; Brown, H. K.; Bergman, P. J.; Hohenhaus, A.; Healey, J. H. |
| Article Title: | Influence of carboplatin infusion on osteosarcoma blood flow |
| Abstract: | Purpose: Herein we report that carboplatin infusion influenced tumor blood flow signal independent of the mechanical decompression induced by the artificial lymphatics system technology that was being evaluated as part of a randomized veterinary clinical trial, treating spontaneously occurring canine appendicular osteosarcoma, a tumor very similar to its human counterpart. Methods: Blood flow within the central region of the tumor was recorded continuously using laser Doppler flowmetry, a real-time measurement technology. Time-averaged flow values were computed from segments taken from the recordings immediately before starting carboplatin infusion, and during infusion. Results: Carboplatin increased the tumor blood flow signal by an additional 59 ± 26% (mean ± SEM; p = 0.06) over the increase induced by the decompression. The increase started within 49 ± 46 s after the start of infusion, had a response time constant of 19 ± 21 s and persisted throughout the infusion, ending shortly after infusion ended. Conclusion: The rapidity of the flow signal increase suggests that carboplatin may have an autonomic effect on circulation, either local or systemic. The observations identify a new action of this drug and suggest a possible mechanism to exploit therapeutically. © 2007 Springer-Verlag. |
| Keywords: | osteosarcoma; controlled study; treatment outcome; bone neoplasms; nonhuman; antineoplastic agents; animals; carboplatin; animal experiment; animal model; time factors; drug delivery systems; dog diseases; dogs; drug infusion; microcirculation; blood flow; infusions, intravenous; electrocardiography; tumor blood flow; doppler flowmetry; canine; artificial lymphatic system; interstitial fluid pressure; capillary flow; laser-doppler flowmetry |
| Journal Title: | Cancer Chemotherapy and Pharmacology |
| Volume: | 62 |
| Issue: | 3 |
| ISSN: | 0344-5704 |
| Publisher: | Springer |
| Date Published: | 2008-01-01 |
| Start Page: | 545 |
| End Page: | 549 |
| Language: | English |
| DOI: | 10.1007/s00280-007-0615-4 |
| PUBMED: | 17932675 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "CODEN: CCPHD" - "Source: Scopus" |
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