Evolving treatment of advanced colon cancer Journal Article
| Authors: | Segal, N. H.; Saltz, L. B. |
| Article Title: | Evolving treatment of advanced colon cancer |
| Abstract: | Colorectal cancer is a common malignancy worldwide. Despite significant developments in the treatment of this disease, it still causes considerable morbidity and mortality. Recent advances include both newer cytotoxic chemotherapies and novel biologic agents. Although overall progress has been more modest than had been hoped, substantial benefits have been achieved for some patients, and the number of treatment options has substantially increased. Perhaps most importantly, treatment regimens can now be selected and tailored toward the individual patient following an informed discussion between the patient and the treating oncologist.We present in detail these recent advances and provide some insight into several promising future strategies. Copyright © 2009 by Annual Reviews. All rights reserved. |
| Keywords: | treatment response; surgical technique; clinical trial; neutropenia; review; bevacizumab; fluorouracil; placebo; advanced cancer; cancer growth; diarrhea; drug efficacy; drug potentiation; drug safety; drug withdrawal; gastrointestinal hemorrhage; hypertension; monotherapy; nonhuman; unspecified side effect; antineoplastic agents; capecitabine; neurotoxicity; colorectal cancer; metastasis; drug eruption; nausea; neuropathy; vomiting; dehydration; 7 ethyl 10 hydroxycamptothecin; camptothecin; colonic neoplasms; combination chemotherapy; continuous infusion; cetuximab; irinotecan; panitumumab; febrile neutropenia; hypomagnesemia; hypotension; antibodies, monoclonal; disease progression; thromboembolism; folinic acid; acne; neoplasm metastasis; stomach cancer; drug half life; oxaliplatin; deoxycytidine; angiogenesis inhibitors; anaphylaxis; digestive system perforation; organoplatinum compounds; fluoropyrimidine; proteinuria; targeted agents; antithrombocytic agent; bronchospasm; venous thromboembolism; anticoagulant agent; combination strategies; planned interruption; sequencing; histamine h3 receptor antagonist; hair loss; metastesectomy |
| Journal Title: | Annual Review of Medicine |
| Volume: | 60 |
| ISSN: | 0066-4219 |
| Publisher: | Annual Reviews |
| Date Published: | 2009-01-01 |
| Start Page: | 207 |
| End Page: | 219 |
| Language: | English |
| DOI: | 10.1146/annurev.med.60.041807.132435 |
| PUBMED: | 19630571 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 30 November 2010" - "CODEN: ARMCA" - "Source: Scopus" |
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