Dermoscopic patterns and subclinical melanocytic nests in normal-appearing skin Journal Article

Authors: Scope, A.; Marghoob, A. A.; Chen, C. S.; Lieb, J. A.; Weinstock, M. A.; Halpern, A. C.
Article Title: Dermoscopic patterns and subclinical melanocytic nests in normal-appearing skin
Abstract: Background Dermoscopic patterns of normal-appearing skin have received little scrutiny. We have recently completed an analysis of dermoscopic patterns of naevi in children. Objectives To describe dermoscopic patterns in the normal-appearing skin surrounding naevi and to explore histological features of patterned background skin. Methods Dermoscopic images of back naevi were obtained from a population-based sample of fifth grade students. The dermoscopic pattern of the background skin around the naevi was analysed. We examined histopathological features of background skin patterns in a convenience sample of seven specimens from six adult patients. Results We observed a dermoscopic pattern in the background of normal-appearing skin in 41% of 1192 dermoscopic images from the backs of the 443 children. The background skin pattern was less frequent in individuals with a fair skin (P < 0·001). A globular pattern was observed in 201 images (17%) and a reticular pattern was seen in 287 images (24%), of which 112 images also showed globules. Inter-rater reliability between the two observers for a random sample of 100 images was excellent (k = 0·77). In four specimens with a globular background pattern, microscopic melanocytic nests were observed in the normal-appearing skin. No subclinical naevus nests were observed in three reticular pattern specimens. Conclusions Dermoscopically recognized patterns are commonly present in clinically normal skin of children. Microscopic melanocytic nests may be observed in normal-appearing skin with a globular skin pattern. © 2009 British Association of Dermatologists.
Keywords: adult; child; controlled study; human tissue; aged; middle aged; major clinical study; clinical feature; histopathology; ultraviolet radiation; dermoscopy; skin pigmentation; skin neoplasms; diagnosis, differential; epiluminescence microscopy; skin; melanocytic nevus; nevus, pigmented; eosin; hematoxylin; children
Journal Title: British Journal of Dermatology
Volume: 160
Issue: 6
ISSN: 0007-0963
Publisher: Blackwell Publishing  
Date Published: 2009-06-01
Start Page: 1318
End Page: 1321
Language: English
DOI: 10.1111/j.1365-2133.2009.09073.x
PUBMED: 19416274
PROVIDER: scopus
PMCID: PMC2909604
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: BJDEA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Allan C Halpern
    385 Halpern
  2. Jocelyn Ann Lieb
    12 Lieb
  3. Alon Scope
    123 Scope
  4. Chih-Shan Jason Chen
    50 Chen
  5. Ashfaq A Marghoob
    507 Marghoob