Histologic grade is correlated with outcome after resection of hepatic neuroendocrine neoplasms Journal Article


Authors: Cho, C. S.; Labow, D. M.; Tang, L.; Klimstra, D. S.; Loeffler, A. G.; Leverson, G. E.; Fong, Y.; Jarnagin, W. R.; D'Angelica, M. I.; Weber, S. M.; Blumgart, L. H.; DeMatteo, R. P.
Article Title: Histologic grade is correlated with outcome after resection of hepatic neuroendocrine neoplasms
Abstract: BACKGROUND. The behavior of neuroendocrine neoplasms is poorly defined, and predictors of outcome after surgical resection have yet to be identified. Consequently, guidelines for treatment remain unclear. Current pathologic classification systems do not permit meaningful discrimination of hepatic neuroendocrine neoplasms. METHODS. The authors reviewed prospectively maintained databases from 2 institutions of patients who underwent hepatic resection for neuroendocrine neoplasms between 1990 and 2006. Patient, tumor, and operative characteristics were analyzed to identify factors associated with overall survival, progression-free survival, and symptom control. Hepatic neoplasms were stratified by using a 3-tier pathologic classification system based on the number of mitotic figures and the presence of tumor necrosis that was recently validated for pancreatic neuroendocrine neoplasms. RESULTS. Seventy patients were identified from the databases. Low-grade, intermediate-grade, and high-grade neoplasms were identified in 53%, 37%, and 10% of patients, respectively. After a median follow-up of 51 months, the median overall survival for all patients was 91 months, and it was 108 months when 7 patients with high-grade neuroendocrine carcinomas were excluded. Progressive disease was eventually observed in 81% of patients, and the median progression-free survival was 17 months. The median time to the onset of symptoms was 39 months for patients who presented with hormonal symptoms and 80 months for all patients. Histologic grade was associated with poorer overall and progression-free survival. CONCLUSIONS. When performed in a context of aggressive multimodality therapy, long-term outcomes after partial hepatectomy for hepatic neuroendocrine neoplasms were favorable; however, disease progression was eventually observed in the majority of patients. Several oncologic variables were associated with significant differences in survival after resection. A novel pathologic classification system appears to enhance prognostic stratification of patients with hepatic neuroendocrine neoplasms. © 2008 American Cancer Society.
Keywords: adult; cancer survival; controlled study; human tissue; treatment outcome; aged; aged, 80 and over; disease-free survival; middle aged; survival analysis; major clinical study; artificial embolism; cancer growth; liver neoplasms; cancer radiotherapy; combined modality therapy; follow up; cancer grading; disease association; pathology; histology; neuroendocrine tumor; postoperative complication; liver; liver tumor; surgery; liver resection; hepatectomy; octreotide; cancer classification; metastases; grade; radiofrequency ablation; neuroendocrine tumors; neuroendocrine; tumor necrosis
Journal Title: Cancer
Volume: 113
Issue: 1
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2008-07-01
Start Page: 126
End Page: 134
Language: English
DOI: 10.1002/cncr.23523
PUBMED: 18457323
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: CANCA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Leslie H Blumgart
    340 Blumgart
  2. Ronald P DeMatteo
    597 DeMatteo
  3. Sharon M Weber
    12 Weber
  4. Daniel M Labow
    7 Labow
  5. David S Klimstra
    843 Klimstra
  6. William R Jarnagin
    583 Jarnagin
  7. Yuman Fong
    741 Fong
  8. Laura Hong Tang
    320 Tang