Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors Journal Article
| Authors: | Untch, B. R.; Bonner, K. P.; Roggin, K. K.; Reidy-Lagunes, D.; Klimstra, D. S.; Schattner, M. A.; Fong, Y.; Allen, P. J.; D'Angelica, M. I.; DeMatteo, R. P.; Jarnagin, W. R.; Kingham, T. P.; Tang, L. H. |
| Article Title: | Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors |
| Abstract: | Background: Duodenal neuroendocrine tumors are rare and few studies exist to guide surgical management. This study identifies factors associated with recurrence after resection. Methods: A retrospective, single institution review was performed between 1983 and 2011 on patients with a pathologic diagnosis of duodenal neuroendocrine tumor. Tumor grade was assigned based on WHO 2010 criteria (Ki-67 and mitotic rate). Results: Seventy-five patients were identified that underwent curative resection. This included 12 patients with endoscopic mucosal resection, 34 that had local resection, and 29 that underwent pancreaticoduodenectomy. Two-year and 5-year recurrence-free survival was 84 and 81 %, respectively. There were 11 tumor recurrences (either local or distant), and four patients died of their disease (3/4 had high-grade lesions) with an overall median follow-up of 27 months. On univariate analysis, tumor size and tumor grade were identified as being associated with recurrence, but not intervention type, lymph node metastases, ampullary location, or margin status. Conclusions: Tumor grade and size are associated with recurrence-free survival in duodenal neuroendocrine tumors. When feasible, a less aggressive surgical approach to treat low-grade and low-stage duodenal NETs should be considered. © 2014 The Society for Surgery of the Alimentary Tract. |
| Keywords: | ki-67; carcinoid tumor; endoscopic mucosal resection; ampullary; tumor grade; duodenal neuroendocrine tumors |
| Journal Title: | Journal of Gastrointestinal Surgery |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 1091-255X |
| Publisher: | Springer |
| Date Published: | 2014-03-01 |
| Start Page: | 457 |
| End Page: | 463 |
| Language: | English |
| DOI: | 10.1007/s11605-014-2456-x |
| PROVIDER: | scopus |
| PUBMED: | 24448999 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work