Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors Journal Article


Authors: Untch, B. R.; Bonner, K. P.; Roggin, K. K.; Reidy-Lagunes, D.; Klimstra, D. S.; Schattner, M. A.; Fong, Y.; Allen, P. J.; D'Angelica, M. I.; DeMatteo, R. P.; Jarnagin, W. R.; Kingham, T. P.; Tang, L. H.
Article Title: Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors
Abstract: Background: Duodenal neuroendocrine tumors are rare and few studies exist to guide surgical management. This study identifies factors associated with recurrence after resection. Methods: A retrospective, single institution review was performed between 1983 and 2011 on patients with a pathologic diagnosis of duodenal neuroendocrine tumor. Tumor grade was assigned based on WHO 2010 criteria (Ki-67 and mitotic rate). Results: Seventy-five patients were identified that underwent curative resection. This included 12 patients with endoscopic mucosal resection, 34 that had local resection, and 29 that underwent pancreaticoduodenectomy. Two-year and 5-year recurrence-free survival was 84 and 81 %, respectively. There were 11 tumor recurrences (either local or distant), and four patients died of their disease (3/4 had high-grade lesions) with an overall median follow-up of 27 months. On univariate analysis, tumor size and tumor grade were identified as being associated with recurrence, but not intervention type, lymph node metastases, ampullary location, or margin status. Conclusions: Tumor grade and size are associated with recurrence-free survival in duodenal neuroendocrine tumors. When feasible, a less aggressive surgical approach to treat low-grade and low-stage duodenal NETs should be considered. © 2014 The Society for Surgery of the Alimentary Tract.
Keywords: ki-67; carcinoid tumor; endoscopic mucosal resection; ampullary; tumor grade; duodenal neuroendocrine tumors
Journal Title: Journal of Gastrointestinal Surgery
Volume: 18
Issue: 3
ISSN: 1091-255X
Publisher: Springer  
Date Published: 2014-03-01
Start Page: 457
End Page: 463
Language: English
DOI: 10.1007/s11605-014-2456-x
PROVIDER: scopus
PUBMED: 24448999
DOI/URL:
Notes: Export Date: 2 April 2014 -- Source: Scopus
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MSK Authors
  1. Ronald P DeMatteo
    605 DeMatteo
  2. Diane Lauren Reidy
    157 Reidy
  3. David S Klimstra
    856 Klimstra
  4. Peter Allen
    445 Allen
  5. William R Jarnagin
    598 Jarnagin
  6. Yuman Fong
    746 Fong
  7. T Peter Kingham
    295 Kingham
  8. Laura Hong Tang
    331 Tang
  9. Mark Schattner
    104 Schattner
  10. Brian Untch
    26 Untch
  11. Keisha Patrice Bonner
    1 Bonner