Molecular basis of metastasis Journal Article
| Authors: | Chiang, A. C.; Massague, J. |
| Article Title: | Molecular basis of metastasis |
| Abstract: | Metastases are the principal cause of death in patients with cancer. Recent advances bring hope that it will be possible to identify the molecules and processes involved in metastasis, and this new knowledge could lead to effective methods of preventing and treating metastases. This review describes the properties of cells that enable them to surmount physical boundaries, disseminate, and colonize a distant organ. Copyright © 2008 Massachusetts Medical Society. |
| Keywords: | review; antineoplastic agents; cancer staging; genetic analysis; animals; metastasis; models, biological; neovascularization, pathologic; cell heterogeneity; extracellular matrix; gene expression regulation, neoplastic; neoplastic stem cells; cancer stem cell; tumor cell; neoplasm metastasis; cell movement; neoplasm invasiveness; cell interaction; cell communication; osteoclast differentiation factor |
| Journal Title: | New England Journal of Medicine |
| Volume: | 359 |
| Issue: | 26 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 2008-12-25 |
| Start Page: | 2814 |
| End Page: | 2823+2752 |
| Language: | English |
| DOI: | 10.1056/NEJMra0805239 |
| PUBMED: | 19109576 |
| PROVIDER: | scopus |
| PMCID: | PMC4189180 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 120" - "Export Date: 17 November 2011" - "CODEN: NEJMA" - "Source: Scopus" |
