Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems Journal Article

   

Authors:	Cayirlioglu, P.; Kadow, I. G.; Zhan, X.; Okamura, K.; Suh, G. S. B.; Gunning, D.; Lai, E. C.; Zipursky, S. L.
Article Title:	Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems
Abstract:	Carbon dioxide (CO2) elicits different olfactory behaviors across species. In Drosophila, neurons that detect CO2 are located in the antenna, form connections in a ventral glomerulus in the antennal lobe, and mediate avoidance. By contrast, in the mosquito these neurons are in the maxillary palps (MPs), connect to medial sites, and promote attraction. We found in Drosophila that loss of a microRNA, miR-279, leads to formation of CO 2 neurons in the MPs. miR-279 acts through down-regulation of the transcription factor Nerfin-1. The ectopic neurons are hybrid cells. They express CO2 receptors and form connections characteristic of CO 2 neurons, while exhibiting wiring and receptor characteristics of MP olfactory receptor neurons (ORNs). We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species-specific behaviors elicited by CO2.
Keywords:	unclassified drug; mutation; nonhuman; mutant protein; phenotype; animals; microrna; gene expression; transcription factor; drosophila; evolution; wild type; transcription factors; rna; gene expression regulation; species specificity; down regulation; upregulation; fly; micrornas; drosophila proteins; neurology; 3' untranslated regions; receptors, cell surface; hexapoda; carbon dioxide; sense organs; animals, genetically modified; mosquito; olfactory receptor; hybrid cell; protein mir 279; transcription factor nerfin 1; olfactory cue; sensory system; antenna; hybrid cells; olfactory receptor neurons
Journal Title:	Science
Volume:	319
Issue:	5867
ISSN:	0036-8075
Publisher:	American Association for the Advancement of Science
Date Published:	2008-02-29
Start Page:	1256
End Page:	1260
Language:	English
DOI:	10.1126/science.1149483
PUBMED:	18309086
PROVIDER:	scopus
PMCID:	PMC2714168
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-40049098982&partnerID=40&md5=998c64fa015eae22a9f5f7d446fff271
Notes:	--- - "Cited By (since 1996): 25" - "Export Date: 17 November 2011" - "CODEN: SCIEA" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/14151